Six drugs viz., Metoprolol tartrate, Torsemide, Diclofenac sodium, Chlorpheniramine, Loratadine and irbesartan were tested for the formation of charge transfer complexes with p-CA and the interaction formed a basis for quantitative determination of the drugs spectrophotometrically. CH3CN was found to be suitable for the analysis. The methods have been validated in terms of ICH guidelunes The complexes were found to have 1:1 composition and have stability of the order 10 5.
Cite this article:
K. Damodar Reddy, Sayaji Rao, G. Venkateshwarlu. Spectrophotometric Determination of Drugs Using p-Chloranilic Acid as Analytical Reagent. Asian J. Research Chem. 4(8): August, 2011; Page 1311-1317.