ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Nesrin Turaçlar, Şahande Elagöz, Hasibe Cingilli Vural

Email(s): drnesrinturaclar@yahoo.com

DOI: Not Available

Address: Nesrin Turaçlar1*, Şahande Elagöz2 and Hasibe Cingilli Vural3
1Vocational School of Health Services, Selcuk University, Konya, Turkey
2Department of Pathology, Cumhuriyet Medical Faculty, Cumhuriyet University, Sivas, Turkey
3Selcuk University, Department of Biology, Molecular Biology, 42079 Selçuklu, Konya, Turkey
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2012


ABSTRACT:
Among all tumours diagnosed worldwide, gastric adenocarcinoma, breast and endometrium are the most frequent types of malignancy. In addition to these cancer types, PTEN frequently is mutated or inactivated in glioblastoma, melanoma, and cancers of the prostate. The severity of PTEN irregularities strongly correlates with the tumor stage and grade. For example, complete loss of PTEN expression is found more frequently in metastatic cancer than in primary tumors. For this reason, the aim of this study was to assess the contribution of PTEN gene to commonly cancer types in the Turk population and investigate mutation of tumor suppressor gene PTEN in gastric cancer, breast cancer and endometrium cancer types. In our study, DNA was obtained from different tissue types such as, gastric adenocarcinoma, breast and endometrium cancer samples, amplified, screened for 2 exons (exon 1 and exon 2) of the PTEN gene by PCR-SSCP and then confirmed by sequencing. There was only one sample that presented an alteration and that was a transversion. Our results corroborate the hypothesis that somatic alterations in the PTEN gene are rare events in gastric cancer. Furthermore, Inherited changes in several other genes, including PTEN have been found to increase the risk of developing breast cancer and endometrium cancer. This case affirmed that, for establishment of a correct diagnosis, especially for rare clinically overlapping syndromes, molecular testing is usually the only reliable method.


Cite this article:
Nesrin Turaçlar, Şahande Elagöz, Hasibe Cingilli Vural. Study on Determination of Mutations of the PTEN Tumor Suppressor Gene in Various Cancer Types. Asian J. Research Chem. 5(3): March 2012; Page 371-376.


Recomonded Articles:

Author(s): Anupam Maurya, Subash C. Verma, Vijay Gupta, M. B. Shankar

DOI: 10.5958/0974-4150.2017.00142.0         Access: Open Access Read More

Author(s): Sarita Yadav, D.K. Tyagi , O.P. Yadav

DOI:         Access: Open Access Read More

Author(s): S. Ganguly, A.K. Banik

DOI:         Access: Open Access Read More

Author(s): Shantaram G. Khanage, Popat B. Mohite, S. Appala Raju

DOI:         Access: Open Access Read More

Author(s): Senthilkumar G., Madhanraj P., Panneerselvam A

DOI:         Access: Open Access Read More

Author(s): Prasad Gundepaka, Srinivas Nerella, Shravankumar Kankala, Mukkanti Kagga, Chandra Sekhar Vasam

DOI:         Access: Open Access Read More

Author(s): Nesrin Turaçlar, Şahande Elagöz, Hasibe Cingilli Vural

DOI:         Access: Open Access Read More

Author(s): A. Gupta, S. K. Das, A. K. Banik

DOI:         Access: Open Access Read More

Author(s): Nikhat Farhana, Thouheed Ansari, Moid Ansari

DOI: 10.5958/0974-4150.2020.00057.7         Access: Closed Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags