ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Dhiraj Raghuvanshi, Pramod Kumar Sharma, Nimita Manocha, Shikha Agrawal, Prerna Chaturvedi

Email(s): dhirajraghuwanshi3@gmail.com

DOI: Not Available

Address: Dhiraj Raghuvanshi1*, Pramod Kumar Sharma1, Nimita Manocha1, Shikha Agrawal2, Prerna Chaturvedi1
1Department of Pharmaceutical Chemistry, Swami Vivekanand College of Pharmacy, Near Toll Naka, Khandwa Road, Indore, M.P. PIN-452020
2Department of Pharmaceutics, Swami Vivekanand College of Pharmacy, Near Toll Naka, Khandwa Road, Indore, M.P. PIN-452020
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012


ABSTRACT:
Some novel series of amino and aldehyde substituted azaphenothiazines were synthesized by condensation of 2-chloro-1-(10H-azaphenothiazin-10yl)ethanone with various amines and aryl aldehydes. As it is known that substituted aldehyde and amine when attached with some alkyl chain or heterocyclic moiety can lead to potentially biological active compound. The structure modification for their better biological activity includes substitution on nitrogen at 10th position coupled with aliphatic/aromatic amine and aromatic aldehydes. The above result established the fact that azaphenothiazine can be a rich source of biologically active compounds. The synthesized compounds were confirmed with IR, 1HNMR and Mass spectroscopy. The bioavailability of compounds was determined by Lipinski rule of 5 using customized software.


Cite this article:
Dhiraj Raghuvanshi, Pramod Kumar Sharma, Nimita Manocha, Shikha Agrawal, Prerna Chaturvedi. Design, Synthesis and Characterization of Some Novel Amino and Aldehyde Substituted Azaphenothiazines. Asian J. Research Chem. 5(4): April 2012; Page 532-536.


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