ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider

Email(s): hinashehnaz@gmail.com

DOI: Not Available

Address: Hina Shahnaz1*, M. Saeed Arayne2, Najma Sultana2 and Amir Haider2
1Department of Chemistry, University of Karachi, Karachi.
2Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012


ABSTRACT:
An in vitro availability of fexofenadine in the presence of quinolones (enoxacin, levofloxacin and sparfloxacin) was carried out on a BP 2005 dissolution test apparatus. Fexofenadine second generation non sedative H1 receptor antagonist is an active carboxylic acid metabolite of terfenadine. These reactions were performed at different pH environment (2, 4, 7.4 and 9) at 37 ºC human physiological temperature, at 48 and 60ºC. By the alteration of Beer’s law through simultaneous equation of two components system the reactions were studied. The ultraviolet method is simple and quite accurate. The results from interaction and kinetic studies reveal that these drug interactions are not temperature dependant, but pH dependant and occur more frequently in more acidic or basic medium.


Cite this article:
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro drug interaction studies of Fexofenadine with Enoxacin, Levofloxacin and Sparfloxacin. Asian J. Research Chem. 5(5): May 2012; Page 687-696.


Recomonded Articles:

Author(s): K. Vijayaraj, A. Jawahar , R. Anantharam , M. Kumara Dhas

DOI: 10.5958/0974-4150.2017.00013.X         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Closed Access Read More

Author(s): Anitha Jebamalai Raj, Sudarsanam Dorairaj

DOI:         Access: Open Access Read More

Author(s): P. Nagaraju, Pasumarthy, NV Gopal, VDN Srinivas, SVN Padma

DOI:         Access: Open Access Read More

Author(s): S Kalidas, B Kameswari, P Devi, B Madhumitha, R Meera, NJ Merlin

DOI:         Access: Open Access Read More

Author(s): RW Lohe, PB Suruse, MK Kale, PR Barethiya, AV Kasture SW Lohe

DOI:         Access: Open Access Read More

Author(s): Nikita N. Patel, Charmy S. Kothari

DOI:         Access: Open Access Read More

Author(s): Shashikant P. Pawar, Tryambakrao J. Patil, Ratnamala S. Bendre

DOI: 10.5958/0974-4150.2018.00003.2         Access: Open Access Read More

Author(s): Ashwin Patel, Alankar Shrivastava, Anurekha Jain, GK Singh

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags