ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Abhijeet Ladke, Anita Ingle, Pranjali Ranaware, Mrinalini Damle

Email(s): mcdamle@rediffmail.com

DOI: Not Available

Address: Abhijeet Ladke, Anita Ingle, Pranjali Ranaware and Mrinalini Damle*
Department of Quality Assurance, AISSMS College of Pharmacy, Pune - 411001, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2012


ABSTRACT:
Purpose: To develop and validate a simple and rapid stability-indicating HPLC method for rosuvastatin and fenofibrate in combination. Method: An isocratic RP-HPLC was developed using Jasco HPLC system with HiQ sil C18 HS (250 ?4.6 mm i.d, 5 µm particle size) column with the mobile phase containing mixture of acetonitrile:water (pH 4.0, adjusted with o- phosphoric acid) (70 : 30% v/v). The flow rate was 1.5ml/min and the eluent was monitored at 287nm. The proposed method was validated as per ICH guidelines. Results: The retention time for rosuvastatin calcium and fenofibrate were 2.28min and 13.06min respectively. The assays exhibited good linearity (r2>0.99) over the studied in a range of 1-10µg/ml. The stress testing of rosuvastatin and fenofibrate was carried out under acidic, alkaline, oxidative, neutral, photolytic and thermal conditions. Rosuvastatin and fenofibrate were well resolved from respective degradation products. Conclusions: The results indicated that this method is a simple, rapid, precise and accurate for determination of rosuvastatin and fenofibrate in bulk and in pharmaceutical dosage forms as well as for the stability studies.


Cite this article:
Abhijeet Ladke, Anita Ingle, Pranjali Ranaware, Mrinalini Damle. Development and validation of stability indicating HPLC method for Rosuvastatin calcium and Fenofibrate in combination. Asian J. Research Chem. 5(5): May 2012; Page 606-610.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): JR Rao, Mohan Kumar, SS Yadav

DOI:         Access: Open Access Read More

Author(s): Effat Souri, Nazanin Shabani Ravari, Farhad Alvandifar, Arsalan Negahban Aghdami, Maliheh Barazandeh Tehrani, Massoud Amanlou

DOI:         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags