ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Urwashi D. Ramteke, S.P. Wate

Email(s): : tiwariurwashi@yahoo.in

DOI: Not Available

Address: Urwashi D. Ramteke*, S.P. Wate
Sharad Pawar College of Pharmacy, Wanadongari, Nagpur(M.S.)
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2013


ABSTRACT:
In this study, reverse phase high performance liquid chromatographic method has been developed and validated for the simultaneous determination of Levocetirizine and Phenylephrine in tablet dosage formulation. HPLC separation was achieved with Serveyor PDA/RI/FL model having Chromoquest 5 Software with 20.0 µl fixed loop injector, plus C18 (250mm×4.6mm, 5µm) column and UV detector as stationary phase and 10mM phosphate buffer (pH adjustedto 5.5) (80:20, v/v) as eluent, at a flow rate of 1.0ml/min. UV detection was performed at 278 nm. The retention time of Levocetirizine and Phenylephrine were found to 4.921 and 2.721min respectively. Results of the analysis were validated statistically and by recovery studies. The stability of Levocetirizine was maintained by carrying out all the operations in amber coloured glass wares with minimal exposure to light. The result of the studies showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which can be used for the routine determination of Levocetirizine and Phenylephrine in bulk and in its pharmaceutical dosage forms.


Cite this article:
Urwashi D. Ramteke, S.P. Wate. RP-HPLC Method Development and Validation for Simultaneous Estimation of Levocetirizne Dihydrochloride and Phenylephrine hydrochloride in their tablet dosage form. Asian J. Research Chem. 6(1): January 2013; Page 01-03.


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