ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): J. M. Derasari, V. B. Patel

Email(s): Email ID Not Available

DOI: Not Available

Address: J. M. Derasari1 and V. B. Patel2*
1Research Scholar, Quality Assurance, Parul Institute of Pharmacy & Research, Limda, Vadodara 391760. Gujarat, India.
2Department of Pharmaceutical Quality Assurance, Babaria Institute of Pharmacy, Varnama, Vadodara 391 240, Gujarat, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 10,     Year - 2013


ABSTRACT:
Two simple, accurate, precise and cost effective spectrophotometric methods have been developed for simultaneous determination of febuxostat and diclofenac potassium in bulk and in pharmaceutical combined dosage form. Sodium hydroxide, 0.1 N, was used as a solvent for both the methods; Simultaneous equation method, Method A and First order derivative method, Method B. The wavelengths selected for detection of febuxostat and diclofenac potassium were respectively 314 nm and 276nm for Method A and 275.92 nm and 260.28 nm for method B. Both the methods obeyed Beer’s law in the concentration range of 2-9 µg/ml with (r2) value of 0.9988 for febuxostat and 5-22.5 µg/ml with a (r2) value of 0.997 for diclofenac potassium in the combined dosage form. The percentage recoveries of febuxostat and diclofenac potassium in marketed formulation were found to be 99.85±0.6357 and 100.09± 0.7454 respectively by Simultaneous equation method and 99.88±0.71 and 100.07±0.4010 respectively by first order derivative method. Both the methods were validated in accordance with ICH guidelines and the results obtained indicated that the developed method is accurate, precise and do not suffer from the interference of excipients. Thus the developed methods can be precisely used for the routine analysis of febuxostat and diclofenac potassium in bulk and in pharmaceutical combined dosage forms.


Cite this article:
J. M. Derasari, V. B. Patel. Spectrophotometric Determination of Febuxostat and Diclofenac Potassium in Their Combined Dosage Form by Simultaneous Equation and First Order Derivative Methods. Asian J. Research Chem. 6(10): October 2013; Page 968-972.


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