Rahul More, J. N. Narendra Sharath Chandra, Shachindra. L. Nargund, L.V.G. Nargund
Rahul More1, J. N. Narendra Sharath Chandra1, Shachindra. L. Nargund2, L.V.G. Nargund1*
1Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II main, 100 Ft Ring Road, BSK II Stage, Bangalore- 560085(India).
2Department of Chemistry, Texas State University, San Marcos, USA
Volume - 6,
Issue - 2,
Year - 2013
We have synthesized various substituted thieno(2,3-d)pyrimidines, first by synthesizing ethyl 2-aminothiophene-3-carboxylate (3), by treatment of diethane with ethyl cynoacetate in presence of triethylamine, acetic acid and DMF. Further, the intermediate Ethyl 2-(ethoxycarbonyl)thiophene-3-carboxylate (5) was prepared by compound (3) refluxed with ethyl chloroformate. The key intermediate 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1H, 3H)-dione (7) was prepared by cyclisation of compound (5) with 3-chloro-4-fluoro aniline. The nucleophilic substitution of compound 3-(3-chloro-4-fluorophenyl) thieno [2, 3-d]pyrimidine-2, 4(1 H, 3 H)-dione (7) with various aromatic amines(8a-m), aminophenol(8n) gives substituted thienopyrimidines(8a-n). The synthesized new compounds were characterized by MP, TLC, IR and NMR spectra.
Cite this article:
Rahul More, J. N. Narendra Sharath Chandra, Shachindra. L. Nargund, L.V.G. Nargund. Synthesis of Substituted Thienopyrimidines and Their Evaluation as Antibacterial. Asian J. Research Chem. 6(2): February 2013; Page 177-181.