Author(s):
H.R. Roopa, J. Saravanan, S. Mohan, Rekha Parmesh
Email(s):
roopad24@gmail.com
DOI:
10.5958/0974-4150.2015.00030.9 
Address:
H.R. Roopa*, J. Saravanan, S. Mohan, Rekha Parmesh
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author
Published In:
Volume - 8,
Issue - 3,
Year - 2015
ABSTRACT:
2-Amino-3-cyano-4, 5-disubstituted thiophene JSR-2 was synthesized using 2-amino-3-cyano-4,5-disubstituted thiophene. First step is preparation of 2-amino-3-cyano-4,5-disubstituted thiophene (JSR-c) which was carried out by condensation of diethylamine, cyclohexanone, Malononitrile and sulphur this compound was refluxed with formamide and acetic anhydride to give 4-Amino-5,6-disubstituted thieno [2,3-d] pyrimidines. Then the parent compound was treated with different substituted aryl aldehydes by microwave irradiation method to yield new series of Schiff bases (JSR 7a-7k). The compounds were characterized IR, 1H NMR and mass spectral data and screened for anti-inflammatory activity.
Cite this article:
H.R. Roopa, J. Saravanan, S. Mohan, Rekha Parmesh. Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity. Asian J. Research Chem 8(3): March 2015; Page 170-174. doi: 10.5958/0974-4150.2015.00030.9
Cite(Electronic):
H.R. Roopa, J. Saravanan, S. Mohan, Rekha Parmesh. Synthesis, Characterization of Some Novel Heterofused Thienopyrimidines for Anti-Inflammatory Activity. Asian J. Research Chem 8(3): March 2015; Page 170-174. doi: 10.5958/0974-4150.2015.00030.9 Available on: https://ajrconline.org/AbstractView.aspx?PID=2015-8-3-4