Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives

Author(s): Shivaji Bhattacharjee, J. Saravanan, S. Mohan, Monica Arora

Email(s): bhattacharjee.shivaji@gmail.com

DOI: Not Available

Address: Shivaji Bhattacharjee, J. Saravanan, S. Mohan, Monica Arora
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2013

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ABSTRACT:
The novel 2-amino-3-carbethoxy-4- phenyl thiophene was synthesized by using a acetophenone and ethyl cyano acetate and the parent compound was reacted with chloroacetic acid and glacial acetic acid, the chloro compound was then substituted with different substituted primary and secondary amines to obtain a series of title compounds [SBJa 1-8]. All the new title compounds were characterized by spectral data and were screened for CNS depressant activity. In conclusion, it can be inferred that the electron donating groups on the phenyl ring at R of the title compounds influenced the CNS depressant activity.


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Cite this article:
Shivaji Bhattacharjee, J. Saravanan, S. Mohan, Monica Arora. Synthesis, Characterization and CNS Depressant Activity of Some New Mannich Bases Derivatives. Asian J. Research Chem. 6(3): March 2013; Page 244-247.


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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