Patel R.C, Patel C.N, Panigrahi B.B., Bhaskar V.H.
Patel R.C *, Patel C.N, Panigrahi B.B. and Bhaskar V.H.
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind baug, Mehsana-384001, Gujarat, India
Department of Pharmaceutical and Medicinal Chemistry, M.P Patel College of Pharmacy, JET, Kapadwanj-387620, Gujarat, India
Volume - 2,
Issue - 4,
Year - 2009
Some New benzhydryl piperazine sulfonamide and carboxamide is synthesized from benzaldehyde and phenyl magnesium chloride (Grignard Reagent) under nitrogen atmosphere to give benzhydrol which on treating with thionyl chloride give corresponding benzhydryl chloride which is directly treated with piperazine and anhydrous potassium carbonate using DMF as solvent to give corresponding 1-benzhydryl piperazine. The nucleophilic substitution reaction of 1-benzhydryl piperazine with different substituted aromatic sulfonyl chloride and acid chloride in presence of triethylamine and dichloromethane to give corresponding benzhydryl piperazine sulfonamide and carboxamide. All the title compounds characterised on the basis of their IR, MASS, 1H NMR spectroscopic data analysis.
Cite this article:
Patel R.C , Patel C.N, Panigrahi B.B., Bhaskar V.H.. Synthesis and SAR Study of Some New Benzhydryl Piperazine Sulfonamide and Carboxamide as Antimicrobial Agents. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 448-451.