ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Prathima Patil, S. Sridhar, V. Anusha, Y. Vishwanatham, Kumara Swamy, D. Suman

Email(s): prathima.patil0@gmail.com

DOI: Not Available

Address: Prathima Patil1*, S. Sridhar2, V. Anusha2, Y. Vishwanatham2, Kumara Swamy2, D. Suman2
1Department of Pharmaceutical Chemistry, Sushrut Institute of Pharmacy, Taddanpally (V), Pulkal (M), Medak-502293
2Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapalli, Secundrabad-14
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2014


ABSTRACT:
Pyrazole is a 5-membered heterocyclic ring three carbon atoms and two adjacent nitrogen centres. Pyrazole is the organic compound with the formula C3H3N2H. Pyrazoles are also the class of compounds that have the ring C3N2 with adjacent nitrogen centre. Pyrazoles are synthesized by the reaction of a, ß-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. In the present study, we synthesized different Pyrazoles derivatives (5a, 5b, 5c) (6a, 6b, 6c, 6e) (7a, 7b, 7d) by treating substituted acetophenones with Phenyl hydrazine a by using glacial acetic acid and ethanol as solvent. The respective substituted acetophenone phenylhydrazone were then treated with Vilsmeier Hack Reagent which gives respective carbaldehydes. Then carbaldehydes were treated with 3 different amine compounds that give new Pyrazole derivatives. The prepared Pyrazole derivatives were recrystallized with ethanol. The final compounds were then characterized by melting point, TLC, IR and NMR spectral data. These compounds were evaluated for anti-inflammatory activity. Some of the newly synthesized compounds showed the significant activity when compared with the standard compounds


Cite this article:
Prathima Patil, S. Sridhar, V. Anusha, Y. Vishwanatham, Kumara Swamy, D. Suman. Synthesis, Characterisaton and Evaluation of Anti-Inflammatory Activity of some new Aryl Pyrazole Derivatives. Asian J. Research Chem. 7(3): March 2014; Page 269-274.

Cite(Electronic):
Prathima Patil, S. Sridhar, V. Anusha, Y. Vishwanatham, Kumara Swamy, D. Suman. Synthesis, Characterisaton and Evaluation of Anti-Inflammatory Activity of some new Aryl Pyrazole Derivatives. Asian J. Research Chem. 7(3): March 2014; Page 269-274.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2014-7-3-4


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