ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Mohammad Yunoos, M. Sowjanya, B. Sushma, K. Pavan Kumar

Email(s): yunoosvja@gmail.com

DOI: Not Available

Address: Mohammad Yunoos*, M. Sowjanya, B. Sushma, K. Pavan Kumar
Department of Pharmaceutical Analysis, Bapatla College of Pharmacy, Bapatla-5222101, Andhra Pradesh, India
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2014


ABSTRACT:
A simple, accurate, rapid and sensitive UV spectrophotometric method has been developed for the estimation of Pitavastatin (PVT) in bulk as well as in Pharmaceutical dosage forms. Pitavastatin is used as Anti-hyperlipidemic agent and HMG-CoA reductase inhibitor. It is available in the market in tablet dosage forms with strength 1mg, 2mg and 4mg. The present research work involves the estimation of Pitavastatin using 0.1N HCL as solvent. An absorption maximum (? max) was found to be 249.5nm. It obeys the Beer’s law in the concentration range of 2-12µg/ml with a correlation coefficient value of 0.9996. Validation of the method has been carried out statistically as per ICH guidelines and the results were found to be satisfactory. The result of mean % recovery was found to be 99.83 + 0.39 % for Pitavastatin which shows that the method was not affected by the presence of common excipients in tablet dosage form. The % RSD for both inter-day and intra-day precision was found to be less than 2%. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.122 µg/mL and 0.371 µg/mL. The method was validated by determining its sensitivity, linearity, accuracy and precision which proves suitability of the developed method for the routine quality control analysis for the estimation of Pitavastatin in bulk and tablet dosage form.


Cite this article:
Mohammad Yunoos, M. Sowjanya, B. Sushma, K. Pavan Kumar. A Validated Simple UV Spectrophotometric Method for the Estimation of Pitavastatin in bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 7(4): April 2014; Page 393-396.


Recomonded Articles:

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags