K. Vijaya Sri, A. Anusha, M. Sudhakar
K. Vijaya Sri*, A. Anusha, M. Sudhakar
Department of Pharmaceutical Analysis Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500 014, Telangana, India.
Volume - 9,
Issue - 1,
Year - 2016
The main objective was to develop and validate the UV-spectrophotometric method for the estimation of linagliptin in bulk and pharmaceutical formulations as per ICH guidelines. acetonitrile was used as solvent. The ?max of linagliptin was found to be 296 nm it was proved linearity in the concentration range 1–10 µg/ml with a correlation coefficient value of 0.999. The accuracy studies of proposed method was performed at three different levels, i.e., 50%, 100% and 150% and recovery was found to be in the range of 100.4%. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.23 and 0.73 µg/ml, respectively. The % RSD less than 2 which indicates the accuracy and precise of the method. The above method was a rapid tool for routine analysis of linagliptin in the bulk and in the pharmaceutical dosage form.
Cite this article:
K. Vijaya Sri, A. Anusha, M. Sudhakar. UV-Spectrophotometry Method for the Estimation of Linagliptin in Bulk and Pharmaceutical Formulations. Asian J. Research Chem. 9(1): Jan., 2016; Page 47-50. doi: 10.5958/0974-4150.2016.00009.2