Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1- [(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones.

Author(s): Rahul A. Waghmare

Email(s): rahulwaghmare100@gmail.com

DOI: 10.5958/0974-4150.2017.00125.0   

Address: Rahul A. Waghmare*
Department of Chemistry, Milind College of Science, Nagsenvana, Aurangabad- 431 002.
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017

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ABSTRACT:
One-pot multicomponent condensation carried for obtaining 5- arylidene -1- [(2-(methylsuphonyl-amino)-thiazol-4-yl)-methyl]-2-thioimidazolidin-4-ones using 2-methyl suphonyl amino-4-isothiocynato methyl thiazole, glycine and aryl aldehydes in acetic acid (Scheme1). Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine with isothiocynate. Synthesized intermediates and final compounds were characterized by I.R, 1HNMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.


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Cite this article:
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1- [(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones. Asian J. Research Chem. 2017; 10(6):739-744. doi: 10.5958/0974-4150.2017.00125.0

Cite(Electronic):
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1- [(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones. Asian J. Research Chem. 2017; 10(6):739-744. doi: 10.5958/0974-4150.2017.00125.0   Available on: https://ajrconline.org/AbstractView.aspx?PID=2017-10-6-5


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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