ABSTRACT:
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of alprazolam from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999 ) between 20 % to 100 % of 0.100 mg of drug substance weight. The percentage recovery of alprazolam in the optimized method was between 100.0 to 100.416 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rele Rajan V., Tiwatane Prathamesh P.. A Validated Non-Aqueous Potentiometric Titration Method for Quantitative Determination of Alprazolam from Pharmaceutical Preparation. Asian J. Research Chem. 2016; 9(11): 597-600. doi: 10.5958/0974-4150.2016.00080.8
Cite(Electronic):
Rele Rajan V., Tiwatane Prathamesh P.. A Validated Non-Aqueous Potentiometric Titration Method for Quantitative Determination of Alprazolam from Pharmaceutical Preparation. Asian J. Research Chem. 2016; 9(11): 597-600. doi: 10.5958/0974-4150.2016.00080.8 Available on: https://ajrconline.org/AbstractView.aspx?PID=2016-9-11-6