0974-4150 (Online)
0974-4169 (Print)

Author(s): Saurabh Mehta

Email(s): ,

DOI: 10.5958/0974-4150.2018.00090.1   

Address: Saurabh Mehta*
Department of Applied Chemistry, Delhi Technological University, Bawana Road, Delhi, 110042 India
*Corresponding Author

Published In:   Volume - 11,      Issue - 2,     Year - 2018

ATP synthase is an important enzyme and is an established drug target. The involvement of this enzyme has been attributed to various serious diseases and physiological conditions, such as cancer, obesity, neurodegenerative disorders, etc. It makes it an attractive drug target whose activity may be modulated by small molecules. A variety of inhibitors reported in the literature have been reviewed, and the important O- and N- containing heterocyclic scaffolds have been identified and are presented here. On examining the scaffolds, it is observed that a variety of 5-membered ring containing compounds to macrocycles inhibit ATP synthase. These include Flavones and Isoflavons, Catechins, Estrogen metabolites, Polyenic ?-pyrones, Amphiphilic cationic dyes, Tertiary amine local anesthetics (TALAs), N-sulfonyl tetrahydrobenzodiazepines, N-[1-Aryl-2-(1-imidazolo)ethyl]-acylguanidine derivatives, O-[1-Aryl-2-(1-imidazolo)ethyl]-thiourethane derivatives and 4-amino benzopyrans.

Cite this article:
Saurabh Mehta. Review of Heterocyclic Scaffolds for the Inhibitors of ATP synthase. Asian J. Research Chem. 2018; 11(2):505-508. doi: 10.5958/0974-4150.2018.00090.1

Recomonded Articles:

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Effat Souri, Nazanin Shabani Ravari, Farhad Alvandifar, Arsalan Negahban Aghdami, Maliheh Barazandeh Tehrani, Massoud Amanlou

DOI:         Access: Open Access Read More

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Closed Access Read More

Author(s): K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar

DOI: 10.5958/0974-4150.2017.00067.0         Access: Open Access Read More

Author(s): Sapna Tyagi, Tanveer Alam, Mohd Azhar Khan, Hina Tarannum, Neha Chauhan

DOI: 10.5958/0974-4150.2018.00092.5         Access: Open Access Read More

Author(s): Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya

DOI: 10.5958/0974-4150.2019.00011.7         Access: Open Access Read More

Author(s): Kalimoddin I. Momin, Abhay S. Bondge, Vikas B. Surawanshi, Jairaj K. Dawale

DOI: 10.5958/0974-4150.2017.00122.5         Access: Open Access Read More

Author(s): Sandip N. Badeliya, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Shashikant P. Pawar, Tryambakrao J. Patil, Ratnamala S. Bendre

DOI: 10.5958/0974-4150.2018.00003.2         Access: Open Access Read More

Author(s): Kouser Unnisa, Tahseen Sameena, Habeeba Sulthana, Hafsa Siddiqua, Maimunna Khatoon

DOI: 10.5958/0974-4150.2017.00044.X         Access: Open Access Read More

Author(s): M. Govindammal, M. Prasath, B. Sathya, M. Selvapandiyan

DOI: 10.5958/0974-4150.2017.00079.7         Access: Open Access Read More

Author(s): Bhavna Patel, Zarna Dedania, Ronak Dedania, Chetan Ramolia, G Vidya Sagar, Mehta RS

DOI:         Access: Open Access Read More

Author(s): N V L Suvarchala Reddy V, Sneha J Anarthe, Ganga Raju M, Akhila M, Pooja Raj G.B.

DOI: 10.5958/0974-4150.2019.00020.8         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles