ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sheeja V. K., Swapna. A. S.

Email(s): swapnasurendran88@gmail.com

DOI: 10.5958/0974-4150.2020.00003.6   

Address: Sheeja V. K.1, Swapna. A. S. 2*
1 . Department of Pharmaceutical Analysis, Grace College of Pharmacy, Palakkad, Kerala, India
2Department of Pharmaceutical Chemistry, Sanjo College of Pharmaceutical Studies, Palakkad, Kerala, India
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
A simple precise and rapid method has been developed for the simultaneous estimation of Clonazepam (CNZ) and Paroxetine (PRX) through Fourier Transform Infrared (FTIR) spectroscopy in tablet formulation. For the determination of the active pharmaceutical ingredients (API), KBr pellets containing known amount of standards and samples were used for acquisition of the FTIR spectra. The method involves the measurements of peaks of nitro group at 1340cm -1 (CNZ) and ring -NH group at 929 cm-1 (PRX). Linearity was observed in the range of 0.10- 0.26mg for Clonazepam 2.5-6.5mg for Paroxetine. The regression equation for the calibration data was y=3.283x + 0.019 with correlation coefficient of 0.995 for Clonazepam and y=0.258x+0.042 with correlation coefficient of 0.996 for Paroxetine. The limits of detection were 0.03mg for Clonazepam and 0.5mg for Paroxetine and the limit of quantitation were 0.5mg and 1.5mg for Clonazepam and Paroxetine respectively. The precision of the method was good. The values of the relative standard deviation did not exceed 2%. The proposed method was successfully applied for the simultaneous estimation of Clonazepam and Paroxetine in its combined tablet dosage form with good accuracy and precision. The developed method was found to be precise and accurate for the simultaneous estimation of Clonazepam and Paroxetine in its combined dosage forms. This technique does not use organic solvents, which is one great advantage over the most common analytical methods. This fact contributes to minimize the generation of organic solvent waste by the industry and thereby reduces the impact of its activities on the environment.


Cite this article:
Sheeja V. K., Swapna. A. S. Method Development and Validation for the Simultaneous Estimation of Clonazepam and Paroxetine in Combined Dosage Form using FT-IR. Asian J. Research Chem. 2020; 13(1): 12-14. doi: 10.5958/0974-4150.2020.00003.6


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DOI: 10.5958/0974-4150 

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