A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of terbutaline sulphate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 50 % to 150 % of 0.400 mg of drug substance weight. The percentage recovery of terbutaline sulphate in the optimized method was between 99.39 to 99.64 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
Cite this article:
Rele Rajan V, Tiwatane Prathamesh P. A Validated Non-aqueous Potentiometric Titration Method for Quantitative Determination of Terbutaline Sulphate from Pharmaceutical Preparation Asian J. Research Chem. 2020; 13(2):82-84. doi: 10.5958/0974-4150.2020.00017.6