Author(s):
Abdelhakim Benarima, Mohamed Nasreddine Raache, Moulay Rachid Kouadri, Yassine Belaiche, Salah Eddine Laouini
Email(s):
benarimaabdelhakim@gmail.com
DOI:
10.52711/0974-4150.2021.00062
Address:
Abdelhakim Benarima1*, Mohamed Nasreddine Raache2, Moulay Rachid Kouadri2, Yassine Belaiche1, Salah Eddine Laouini1
1Department of Process Engineering and Petrochemistry, Faculty of Technology, University of Echahid Hamma Lakhdar, El-Oued, BP 789, El-Oued, 39000, Algeria.
2Process Engineering Laboratory (PEL), Kasdi Merbah University, Ouargla, 30000, Algeria.
*Corresponding Author
Published In:
Volume - 14,
Issue - 5,
Year - 2021
ABSTRACT:
Moringa oleifera is considered one of the most useful plants in the world because it's rich in bioactive substances, which employing on modern medical treatment, also can be used for many fields: pharmaceutical, food and cosmetics purposes. In this study, the response surface methodology (RSM) based on a Box–Behnken design (BBD) was employed to optimize the extraction time (X1: 20–60 min), extraction temperature (X2: 15–45 °C) and solvent-solid ratio (X3: 5–7 ml/g), to obtain a high crude of flavonoids yield from Moringa oleifera Leaves by ultrasonic-assisted extraction technique (UAE). The optimum conditions were an extraction time 23 (min), extraction temperature 44 (°C) and solvent-solid ratio 5.05 (ml/g). Under these conditions, the experimental yield was 72.65 (mg ER/g), well matched with the predicted yield 74.34 (mg ER/g) with the coefficients of determination (R2= 0.9861), thus indicating the suitability of response surface methodology in optimizing the ultrasound-assisted extraction of flavonoids from Moringa oleifera Leaves.
Cite this article:
Abdelhakim Benarima, Mohamed Nasreddine Raache, Moulay Rachid Kouadri, Yassine Belaiche, Salah Eddine Laouini. Optimization of Ultrasonic-Assisted Extraction of Flavonoids from Moringa oleifera Leaves Using Response Surface Methodology. Asian Journal of Research in Chemistry. 2021; 14(5):363-7. doi: 10.52711/0974-4150.2021.00062
Cite(Electronic):
Abdelhakim Benarima, Mohamed Nasreddine Raache, Moulay Rachid Kouadri, Yassine Belaiche, Salah Eddine Laouini. Optimization of Ultrasonic-Assisted Extraction of Flavonoids from Moringa oleifera Leaves Using Response Surface Methodology. Asian Journal of Research in Chemistry. 2021; 14(5):363-7. doi: 10.52711/0974-4150.2021.00062 Available on: https://ajrconline.org/AbstractView.aspx?PID=2021-14-5-11
REFERENCES:
1. Benarima, A., Laouini, S. E., Raache, M. N., & Kouadri, M. R. Influence of Extraction temperature on the Phenolic compounds and Antioxidant Capacity from Moringa oleifera Leaves. Asian Journal of Research in Chemistry, 2021;14(2), 120-124.
2. Benarima A, Laouini SE, Ben seghir B, Belaiche Y, Ouahrani M. Optimization of Ultrasonic-Assisted Extraction of Phenolic Compounds from Moringa oleifera Leaves using Response Surface Methodology. Asian Journal of Research in Chemistry, 2020;13(5):13-17.
3. Naeem S, Ali M, Mahmood A. Optimization of extraction conditions for the extraction of phenolic compounds from Moringa oleifera leaves. Pak J Pharm Sci. 2012; 25(3):535-541.
4. Reddy MS, Kuber BR. Evaluation of Anti-Bacterial Activity of Leaf Extracts of Mimusops elengi and Moringa oleifera. Res J Pharmacogn Phytochem. 2016; 8(1):13-15.
5. Cui C, Chen S, Wang X, et al. Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect. Int J Biol Macromol. 2019;132:844-851.
6. Rastogi T, Ghorpade DS, Deokate UA, Khadabadi SS. Studies on antimicrobial activity of Boswellia serrata, Moringa oleifera and Vitex negundo: a comparison. Res J Pharmacogn Phytochem. 2009;1(1):75-77.
7. Manjula B, Hunasagi R, Shivalinge GKP. Anti-Obesity Activity of Ethanolic Extract of Moringa oleifera Seeds In Experimental Animals. Res J Pharmacol Pharmacodyn. 2011;3(6):318-328.
8. Rastogi T, Bhutda V, Moon K, Aswar PB, Khadabadi SS. Comparative studies on anthelmintic activity of Moringa oleifera and Vitex negundo. Asian J Res Chem. 2009;2(2):181-182.
9. Narapusetty N, Sivaiah O, Balanasaraiah B, et al. Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model. Asian J Pharm Res. 2017;7(2):88-93.
10. Rodríguez-Pérez C, Gilbert-López B, Mendiola JA, Quirantes-Piné R, Segura-Carretero A, Ibáñez E. Optimization of microwave-assisted extraction and pressurized liquid extraction of phenolic compounds from Moringa oleifera leaves by multiresponse surface methodology. Electrophoresis. 2016;37(13):1938-1946.
11. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:1-10.
12. Cassol L, Rodrigues E, Zapata Noreña CP. Extracting phenolic compounds from Hibiscus sabdariffa L. calyx using microwave assisted extraction. Ind Crops Prod. 2019;133:168-177.
13. Nuapia Y, Cukrowska E, Tutu H, Chimuka L. South African Journal of Botany Statistical comparison of two modeling methods on pressurized hot water extraction of vitamin C and phenolic compounds from Moringa oleifera leaves. South African J Bot. 2020; 129:9-16.
14. Xavier L, Freire MS, González-Álvarez J. Modeling and optimizing the solid–liquid extraction of phenolic compounds from lignocellulosic subproducts. Biomass Convers Biorefinery. 2019; 9(4): 737-747.
15. Argade PA, Bhutkar MA, Magdum CS. Albizzia lebbeck extract mediated synthesis of Zinc Oxide Nanoparticles and study of its In-vitro Anti-diabetic and Anti-oxidant activity. Asian J Pharm Technol. 2019;9(2):93-98.
16. Uysal S, Cvetanović A, Zengin G, Zeković Z, Mahomoodally MF, Bera O. Optimization of Maceration Conditions for Improving the Extraction of Phenolic Compounds and Antioxidant Effects of Momordica Charantia L. Leaves Through Response Surface Methodology (RSM) and Artificial Neural Networks (ANNs). Anal Lett. 2019;52(13):2150-2163.
17. Khan MK, Abert-Vian M, Fabiano-Tixier AS, Dangles O, Chemat F. Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L.) peel. Food Chem. 2010;119(2):851-858.
18. Amina B-B, Roukia H, Mahfoud HA, Ahlem T, Chahrazed B, Houria M. Optimization of Extraction conditions of the Polyphenols, Flavonoids and the Antioxidant activity of the plant Ammosperma cinereum (Brassicaceae) through the Response Surface Methodology (RSM). Asian J Res Chem. 2020;13(1):1-6.
19. Motahari, Kazem; Barati S. Optimization of Nusselt Number of Al 2 O 3 / Water Nanofluid Using Response Surface Methodology. Iran J Chem Chem Eng. 2019;38(3):309-317.
20. Guemari F, Laouini SE, Rebiai A, Bouafia A. Phytochemical screening and Identification of Polyphenols, Evaluation of Antioxidant activity and study of Biological properties of extract Silybum marianum (L.). Asian J Res Chem. 2020;13(3):190-197.
21. Jang S, Lee AY, Lee AR, Choi G, Kim HK. Optimization of ultrasound-assisted extraction of glycyrrhizic acid from licorice using response surface methodology. Integr Med Res. 2017;6(4):388-394.
22. Bover E, Padr PC, Jose C, Lloris M. Extraction of polyphenols in Himanthalia elongata and determination by High Performance Liquid Chromatography with Diode Array Detector prior to its potential use against oxidative stress. J Chromatogr B. 2016; 1033: 334-341.
23. Yan YL, Yu CH, Chen J, Li XX, Wang W, Li SQ. Ultrasonic-assisted extraction optimized by response surface methodology, chemical composition and antioxidant activity of polysaccharides from Tremella mesenterica. Carbohydr Polym. 2011;83(1):217-224.
24. Baran A, Goud DV V, Das C. Extraction and characterization of phenolic content from purple and black rice (Oryza sativa L) bran and its antioxidant activity. J Food Meas Charact. 2018;12(1):332-345.
25. Xi J, He L, Yan L. Continuous extraction of phenolic compounds from pomegranate peel using high voltage electrical discharge. Food Chem. 2017; 230:354-361.
26. Li H, Zhang Z, Xue J, et al. Optimization of ultrasound-assisted extraction of phenolic compounds, antioxidants and rosmarinic acid from perilla leaves using response surface methodology. Food Sci Technol. 2016;36(4):686-693.