ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Omar Mechraoui, Ali Imessaoudene, Mohamed Y. Maiz, Hicham Banouh, Lotfi Mouni, Abdelkrim Rebiai, Mohamed L. Belfar, Noureddine Elboughdiri, Djamel Ghernaout, Bachir Ben Seghir

Email(s): bbachir39@gmail.com

DOI: 10.52711/0974-4150.2021.00069   

Address: Omar Mechraoui1, Ali Imessaoudene2, Mohamed Y. Maiz2, Hicham Banouh2, Lotfi Mouni2, Abdelkrim Rebiai3, Mohamed L. Belfar4, Noureddine Elboughdiri5,6, Djamel Ghernaout5,7, Bachir Ben Seghir8,9,10*
1Faculty of Technology, University Amar Telidji-Laghouat, P.O. Box 37G, Laghouat 03000, Algeria.
2Laboratory of Management and Valorization of Natural Resources and Quality Assurance, SNVST Faculty, University of Bouira, Bouira 10000, Algeria.
3Chemistry Department, Faculty of Exact Sciences, University of El Oued, P.O. Box 789, El Oued 39000, Algeria.
4Department of Chemistry, Faculty of Mathematics and Material Science, University Kasdi Merbah Ouargla, P.O. Box 511, Ouargla 30000, Algeria.
5Chemical Engineering Department, College of Engineering, University of Ha’il, P.O. Box 2440, Ha'il 81441, Saudi Arabia.
6Chemical Engineering Process Department, National School of Engineering Gabes, University of Gabes, Gabes 6011, Tunisia.
7Chemical Engineering Department, Faculty of Engin

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
Plants are a large source of new bioactive molecules with therapeutic potentials. However, only a small amount of worldwide plants has been phytochemically investigated. The ethanolic extracts from leaves and flowers of Paronychia argentea were evaluated for their antilithiasic activity in vitro. The effect of extract (0.1, 0.2, 0.3, 1, 2, and 5mg/mL) was studied by the measurement of turbidity in presence or absence of extract at 620nm using UV/Vis spectrophotometer. Total phenol and flavonoid contents were also evaluated. Polyphenol content was found to be more present in the leaves extract (9.29±0.009mg of Gallic acid equivalent (GAE)/g) compared to the flowers extract (5.92±0.14mg GAE/g). Flavonoids content was also found to be more present in the floral extract that is estimated at 0.18±0.01 mg QE/g compared to the flowers extract (0.47±0.0035mg QE/g). For the antilithiasis activity, the results clearly shown that P. argentia extracts inhibited calcium oxalate crystallization by concentration-dependent manner. The maximum percent inhibition of calcium oxalate by flowers extract was found to be 70.97% at 5mg/mL. Further, P. argentea leaf extract has shown antilithiasic properties and may be used for the prevention of kidneys stones. Plants are a large source of new bioactive molecules with therapeutic potentials. However, only a small amount of worldwide plants has been phytochemically investigated. The ethanolic extracts from leaves and flowers of Paronychia argentea were evaluated for their antilithiasic activity in vitro. The effect of extract (0.1, 0.2, 0.3, 1, 2, and 5mg/mL) was studied by the measurement of turbidity in presence or absence of extract at 620 nm using UV/Vis spectrophotometer. Total phenol and flavonoid contents were also evaluated. Polyphenol content was found to be more present in the leaves extract (9.29±0.009mg of Gallic acid equivalent (GAE)/g) compared to the flowers extract (5.92±0.14mg GAE/g). Flavonoids content was also found to be more present in the floral extract that is estimated at 0.18±0.01mg QE/g compared to the flowers extract (0.47±0.0035mg QE/g). For the antilithiasis activity, the results clearly shown that P. argentia extracts inhibited calcium oxalate crystallization by concentration-dependent manner. The maximum percent inhibition of calcium oxalate by flowers extract was found to be 70.97% at 5mg/mL. Further, P. argentea leaf extract has shown antilithiasic properties and may be used for the prevention of kidneys stones.


Cite this article:
Omar Mechraoui, Ali Imessaoudene, Mohamed Y. Maiz, Hicham Banouh, Lotfi Mouni, Abdelkrim Rebiai, Mohamed L. Belfar, Noureddine Elboughdiri, Djamel Ghernaout, Bachir Ben Seghir. In vitro Antiurolithiatic activity of the leaves and flowers extracts of Paronychia argentea, a plant used in traditional medicine in Algeria. Asian Journal of Research in Chemistry. 2021; 14(6):401-1. doi: 10.52711/0974-4150.2021.00069

Cite(Electronic):
Omar Mechraoui, Ali Imessaoudene, Mohamed Y. Maiz, Hicham Banouh, Lotfi Mouni, Abdelkrim Rebiai, Mohamed L. Belfar, Noureddine Elboughdiri, Djamel Ghernaout, Bachir Ben Seghir. In vitro Antiurolithiatic activity of the leaves and flowers extracts of Paronychia argentea, a plant used in traditional medicine in Algeria. Asian Journal of Research in Chemistry. 2021; 14(6):401-1. doi: 10.52711/0974-4150.2021.00069   Available on: https://ajrconline.org/AbstractView.aspx?PID=2021-14-6-2


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