ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rele Rajan V., Tiwatane Prathamesh P

Email(s): drvinraj@gmail.com

DOI: 10.52711/0974-4150.2023.00025   

Address: Rele Rajan V., Tiwatane Prathamesh P
Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai 400016.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2023


ABSTRACT:
Simple sensitive and accurate spectrophotometric methods have developed for the estimation of molnupiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0µg/ml, 2 -14µg/ml, 1-10µg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of molnupiravir in tablets.


Cite this article:
Rele Rajan V., Tiwatane Prathamesh P. Simple Extractive Spectrophotometric Method for Determination of Molnupiravir from Pharmaceutical Formulation. Asian Journal of Research in Chemistry 2023; 16(2):155-8. doi: 10.52711/0974-4150.2023.00025

Cite(Electronic):
Rele Rajan V., Tiwatane Prathamesh P. Simple Extractive Spectrophotometric Method for Determination of Molnupiravir from Pharmaceutical Formulation. Asian Journal of Research in Chemistry 2023; 16(2):155-8. doi: 10.52711/0974-4150.2023.00025   Available on: https://ajrconline.org/AbstractView.aspx?PID=2023-16-2-9


REFERENCES:
1.    R.C. Group. Lopinavir-ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomized, controlled, open-label, platform trial. Lancet. 396 (10259); 2020 :1345–1352.
2.     Chen J, Xia L, Liu L, Xu Q, Ling Y, Huang D, Huang W, Song S, Xu S, Shen Y, Lu H. Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19. Open Forum Infect Dis. 7 (7; 2020; 241
3.    Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, et al. Remdesivir for the Treatment of Covid-19 - Final Report. The New England journal of medicine. 383 (19); 2020; 1813–1826.
4.    Toots M, Yoon J-J, Cox RM, Hart M, Sticher ZM, Makhsous N, Plesker R, Barrena AH, Reddy PG, Mitchell DG, Shean RC, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 11 (515); 2019; 5866.
5.    Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Schafer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med.12 (541); 2020
6.    Painter GR, Bowen RA, Bluemling GR, DeBergh J, Edpuganti V, Gruddanti PR, Guthrie DB, Hager M, Kuiper DL, Lockwood MA, Mitchell DG, et al. The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection. Antiviral Res.; 171; 2019: 104597.
7.    Painter WP, Holman W, Bush JA, Almazedi F, Malik H, Eraut NCJE, Morin MJ, Szewczyk LJ, Painter GR. Human Safety, Tolerability, and Pharmacokinetics of a Novel Broad-Spectrum Oral Antiviral Compound, Molnupiravir, with Activity Against SARS-CoV-2. medRxiv..12.10; 2020:.20235747.
8.    Amara et al. J Pharm Biomed Anal. 2021 9.
9.    Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Meade-White K, Okumura A, Leventhal S, Hawman DW, Ricotta E, et al. Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model. Res Sq. .3; 2020:86289.
10.    Alieu Amaraa, Sujan Dilly Penchalaa, Laura Elsea, Colin Haleb, Richard FitzGeraldb, Lauren Walkerb, Rebecca Lyonsb, Tom Fletcherc, Saye Khoo, The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva, J Pharm Biomed Anal. 206; 2021: 114356. doi:10.1016/j.jpba.2021.11435628.
11.    Tuba Reçber a, 1, Selin Seda Timur b, 1, Sevilay Erdo˘gan Kablan a, Fatma Yalçın c, Tutku Ceren Karabulut c, d, R. Neslihan Gürsoy b, Hakan Ero˘glu b, Sedef Kır a, A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies, journal of pharmaceutical and biomedical analysis, 214; (2022): 114693.
12.    Rele Rajan V., Tiwatane Prathamesh P. Determination of Molnupiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method, Asian journal of research in chemistry:14(5), 2021:321-323.
13.    Rele Rajan V., Tiwatane Prathamesh P. A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation, Asian journal of research in chemistry 15(1): 2022; 49-51.
14.    Rele Rajan V., Tiwatane Prathamesh P.Simple Extractive spectrophotometric method for determination of favipiravir from pharmaceutical formulation Asian Journal of Research Chem. 2022; 15(4):2022; 299-302. DOI: 10.52711/0974-4150.2022.00053.
 

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