ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rele Rajan V., Tiwatane Prathamesh P.

Email(s): drvinraj@gmail.com

DOI: 10.52711/0974-4150.2024.00017   

Address: Rele Rajan V.*, Tiwatane Prathamesh P.
Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2024


ABSTRACT:
Simple sensitive and accurate ion pair complex formation, extractive spectrophotometric methods have developed for the estimation of methdilazine hydrochloride in pharmaceutical dosage form. The methods are based on the formation of ion paired coloured complexes by the drug with reactive dyes like Congo red, picric acid and methyl orange in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 490 nm, 400 nm, and 430 nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition method. The linearity was found to be 1-10 µg/ml, 2-12 µg/ml, and 1-14 µg/ml for methods respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of methdilazine hydrochloride in pharmaceutical dosages.


Cite this article:
Rele Rajan V., Tiwatane Prathamesh P. Determination of Methdilazine by Extractive Colorimetric Method from Pharmaceutical Dosage Form. Asian Journal of Research in Chemistry. 2024; 17(2):85-8. doi: 10.52711/0974-4150.2024.00017

Cite(Electronic):
Rele Rajan V., Tiwatane Prathamesh P. Determination of Methdilazine by Extractive Colorimetric Method from Pharmaceutical Dosage Form. Asian Journal of Research in Chemistry. 2024; 17(2):85-8. doi: 10.52711/0974-4150.2024.00017   Available on: https://ajrconline.org/AbstractView.aspx?PID=2024-17-2-5


REFERENCES:
1.    The United States Pharmacopoeia XXIV Revision. The National Formulary XIX Rockville, USP Convention, 2000.
2.    R. T. Sane, L. S. Joshi, R. M. Kothurkar, K. D. Ladage, R. V. Tendolkar, and D. P. Gangal, “HPLC determination of methdilazine HCl in pharmaceutical dosage forms,” Indian Journal of Pharmaceutical Sciences. 52(3); 1990: 160–161.
3.    K. Croes, P. T. McCarthy, and R. J. Flanagan, “HPLC of basic drugs and quaternary ammonium compounds on microparticulate strong cation-exchange materials using methanolic or aqueous methanol eluents containing an ionic modifier,” Journal of Chromatography A. 693(2); 1995: 289–306.
4.    N. W. Smith and M. B. Evans.  The efficient analysis of neutral and highly polar pharmaceutical compounds using reversed-phase and ion-exchange electrochromatography. Chromatographia. 1995; 41(3): 197–203.
5.    H. Y. Mohammed and F. F. Cantwell. Liquid chromatographie analysis of pharmaceutical syrups using pre-columns and salt-adsorption on amberlite XAD-2. Analytical Chemistry. 1978; 50(3): 491–496.
6.    C. S. P. Sastry, A. S. R. Prasad Tipirneni, M. V. Suryanarayana, T. Thirupathi Rao, and T. Satyanarayana. Spectrofluorimetric determination of trimeprazine tartrate and methdilazine hydrochloride in formulations. Indian Journal of Pharmaceutical Sciences. 1990; 52(2): 115–117.
7.    D. F. Gurka, R. E. Kolinski, J. W. Myrick, and C. E. Wells. Scope of differential UV and differential fluorescence assays for phenothiazines: comparison with official methods. Journal of Pharmaceutical Sciences. 1980; 69 (9): 1069– 1074.
8.    J. Emmanuel and R. Mathew. Spectrophotometric determination of methdilazine hydrochloride in Pharmaceutical Formulations. Indian Drugs. 1985; 22: 602–605.
9.    C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana. Spectrophotometric determination of trimeprazine and methdilazine with sodium cobaltinitrite. Eastern Pharmacist. 1989; 32: 131–133.
10.    C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana. Sensitive spectrophotometric determination of some antihistamines with haematoxylin and chloramines-T. Indian Drugs. 1989; 36: 351–357.
11.    C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana. Spectrophotometric determination of some antiallergic agents with 3-methyl-2-benzothiazolinone hydrazine. Journal of Pharmaceutical and Biomedical Analysis. 1990; 8(3): 287–289.
12.    K. Basavaiah and V. S. Charan. Visible spectrophotometric determination of methdilazine in dosage forms using metavanadate and H2O2. Indian Drugs. 2002; 39 (8): 449–451.
13.    K. Basavaiah and V. S. Charan. Four new vanadometric methods for the assay of methdilazine in bulk drug and in pharmaceutical formulations. Science Asia. 2003; 29: 37–44.
14.    K. Basavaiah and V. S. Charan. Four simple procedures for the assay of methdilazine in bulk drug and in tablets and syrup using potassium iodate. Farmaco. 2003; 58(4):285–292.
15.    K. Basavaiah and V. S. Charan. The use of chloranilic acid for the spectrophotometric determination of three antihistamines. Turkish Journal of Chemistry. 2002; 26(5): 653– 661.
16.    B. G. Gowda and J. Seetharamappa. Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations. Analytical Sciences.19; 2003: 461–464.
17.    K. C. Ramesh, B. G. Gowda, M. B. Melwanki, J. Seetharamappa, and J. Keshavayya. Extractive spectrophotometric determination of antiallergic drugs in pharmaceutical formulations using bromopyrogallol red and bromothymol blue. Analytical Sciences. 2001; 17(9):1101–1103.
18.    C. S. P. Sastry, T. A. S. R. Prasad, and M. V. Suryanarayana. Extraction-spectrophotometric determination of some antihistaminic agents with fast green FCF. Mikrochimica Acta. 1999; 100(1-2):107–112.
19.    K. Basavaiah and V. S. Charan. Spectrophotometric and turbidimetric determination of methdilazine using bromophenol blue. Indian Pharmacist. 2003; 97–100.
20.    C. S. P. Sastry, A. S. R. Prasad Tipirneni, and M. V. Suryanarayana. Spectrophotometric determination of some antihistamines with cobalt thiocyanate. Indian Journal of Pharmaceutical Sciences. 1989; 51(4): 146–148.
21.    S. Singh, B. Singh, R. Bahuguna, L. Wadhwa, and R. Saxena. Stress degradation studies on ezetimibe and development of a validated stability-indicating HPLC assay. Journal of Pharmaceutical and Biomedical Analysis. 2006; 41(3); 1037–1040.
22.    A. Mohammadi, I. Haririan, N. Rezanour, L. Ghiasi, and R. B. Walker. A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules. Journal of Chromatography A. 2006; 1116(1-2): 153–157.
23.    I. Ivana, Z. Ljiljana, and Z. Mira. A stability indicating assay method for cefuroxime axetil and its application to analysis of tablets exposed to accelerated stability test conditions. Journal of Chromatography A. 2006; 1119(1-2): 209–215.
24.    K. B. Vinay, H. D. Revanasiddappa, C. M. Xavier, P. J. Ramesh, and M. S. Raghu. A stability indicating UPLC method for the determination of tramadol hydrochloride: application topharmaceutical analysis. Chromatography Research International. 2012, Article ID 870951; 2012: 9.
25.    Stability testing of new drug substances and products, in Proceedings of the International Conference on Harmonization Q1A (R2), IFPMA, Geneva, Switzerland, 2006.
26.    Rajan V. Rele, S.S. Zarapker Vipul Doshi, V.M. Shah. A simple extractive colorimetric determination of three drug from pharmaceutical preparations. Indian Drug. 1987; 24(12): 560-564.
27.    Rajan V. Rele, Pankaj Gurav. A simple extractive spectrophotometric determination of loradatadine desloratadine and Rupatadine from Pharmaceutical Formulation. International Journal of Pharma and Biosciences. 2012; 3(2): 89-92.
28.    Rele Rajan V. Tiwatane Prathamesh P. Determination of Favipiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method. Asian J. Research Chem. 2021; 14(5): 321-323. DOI: 10.52711/0974-4150.2021.00054.
29.    Rele Rajan V. Tiwatane Prathamesh P. Application of reactive dyes in Validation of favipiravir from pharmaceutical dosages. Asian J. Research Chem. 2023; 16(1): 27-30. DOI: 10.52711/0974-4150.2023.00005
30.    Rele Rajan V. Tiwatane Prathamesh P. Simple Extractive Spectrophotometric Method for Determination of Molnupiravir from Pharmaceutical Formulation. Asian J. Research Chem.  2023; 16(2): 155-158. DOI: 10.52711/0974-4150.2023.00025.



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