ABSTRACT:
The purpose of this research was to find a better way to measure the rate of water absorption in swellable polymer matrices using a less complicated approach. When it comes to kinetic research, the current methods, such as optical microscopy, spatula techniques, and nuclear magnetic resonance imaging, can be quite labour-intensive and complicated. This problem was solved by introducing a technique that makes use of both perforated and non-perforated plastic sheets. On the 2 cm² sheets, black circles with different diameters were printed. On top of these circles, in a Petri dish filled with water, were inserted polymer compacts. The water absorption (W) was measured by removing and weighing the sheets and compacts at predetermined intervals. U, the average water penetration velocity, and Q, the mass degree of swelling, were computed from these values. This technique allowed for the front of the erosion to remain undisturbed while the water absorption kinetics were monitored continuously until the compacts were completely worn away. The results demonstrated that there was no notable distinction (p<0.05) in W, U, and Q between the perforated and non-perforated sheets. After an initial burst of rapid water uptake, swelling peaked at five hours, and then began to fall as a result of the gelled layer's polymer chain degradation. A potential alternative to traditional methods for investigating the kinetics of water absorption in polymer matrices, this approach is user-friendly, sensitive, and straightforward.
Cite this article:
S. Y. Patil, R. K. Jat. A Simplified Approach to Evaluating Water Absorption Kinetics in Swellable Polymer Matrices. Asian Journal of Research in Chemistry.2025; 18(2):109-3. doi: 10.52711/0974-4150.2025.00018
Cite(Electronic):
S. Y. Patil, R. K. Jat. A Simplified Approach to Evaluating Water Absorption Kinetics in Swellable Polymer Matrices. Asian Journal of Research in Chemistry.2025; 18(2):109-3. doi: 10.52711/0974-4150.2025.00018 Available on: https://ajrconline.org/AbstractView.aspx?PID=2025-18-2-9
REFERENCES:
1. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000; 50(1): 27-46.
2. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001; 48(2-3): 139-57.
3. Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Tech Prod Mfr. 1984; 5(3): 1-9.
4. Colombo P, Bettini R, Santi P, Peppas NA. Swellable matrices for controlled drug delivery: gel-layer behavior, mechanisms and optimal performance. Pharm Sci Technol Today. 2000; 3(6): 198-204.
5. Lin SY, Ayres JW, Langer R. Preparation and characterization of poly(ether-urethane) and poly(ether-urethaneurea) swellable membranes for controlled release of macromolecules. J Pharm Sci. 1994; 83(12): 1680-5.
6. Siepmann J, Kranz H, Peppas NA, Bodmeier R. Calculation of the required size and shape of hydroxypropyl methylcellulose matrices to achieve desired drug release profiles. Int J Pharm. 2000; 201(2): 151-64.
7. Ford JL, Rubinstein MH, Hogan JE. Propranolol hydrochloride and aminophylline release from matrix tablets containing hydroxypropylmethylcellulose. Int J Pharm. 1985; 24(3): 339-50.
8. Reynolds TD, Gehrke SH, Hussain AS, Shenouda LS. Polymer erosion and drug release characterization of hydroxypropyl methylcellulose matrices. J Pharm Sci. 1998; 87(9): 1115-23.
9. Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Tech Prod Mfr. 1984; 5(3): 1-9.
10. Siepmann J, Peppas NA. Hydrophilic matrices for controlled drug delivery: an improved mathematical model to predict the resulting drug release kinetics (the "sequential layer" model). Pharm Res. 2000; 17(10): 1290-8.
11. Gurny R, Doelker E, Peppas NA. Modelling of sustained release of water-soluble drugs from swellable polymeric matrices. Biomaterials. 1982; 3(1): 27-32.
12. Ritger PL, Peppas NA. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 1987; 5(1): 37-42.
13. Peppas NA, Korsmeyer RW. Dynamically swelling hydrogels in controlled release applications. Hydrogels Med Pharm. 1987; 3: 109-36.
14. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983; 15(1): 25-35.
15. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001; 48(2-3): 139-57.
16. Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J Pharm Sci. 1995; 84(8): 991-7.
17. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001; 48(2-3): 139-57.
18. Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J Pharm Sci. 1995; 84(8): 991-7.
19. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001; 48(2-3): 139-57.
20. Colombo P, Bettini R, Massimo G, Catellani PL, Santi P, Peppas NA. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J Pharm Sci. 1995; 84(8): 991-7.