ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): V Kiran Kumar, N Appala Raju, Namratha Rani, JVLN Seshagiri Rao, T Satyanarayana

Email(s): kiranphd@yahoo.com

DOI: Not Available

Address: V Kiran Kumar1, N Appala Raju2*, Namratha Rani2, JVLN Seshagiri Rao3 and T Satyanarayana2
1Dept. of Pharma. Chem., Sree Chaitanya Institute of Pharmaceutical Sciences, LMD.Colony, Karimnagar-505527.AP.
2Dept. of Pharma. Chem., Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road# 3, Banjara Hills, Hyderabad-500 034.
3University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam. AP.
* Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009


ABSTRACT:
A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Irinotecan HCl in tablet dosage form. A X-Terra RP C18, 250x4.6 mm i.d, 5 m partical size, with mobile phase consisting of Methanol and 0.01 M Ammonium Acetate containing 0.1% formic acid and methanol in the ratio of 50:50 v/v was used. The flow rate was 1 ml/min and the effluents were monitored at 250 nm. The retention time was 4.69 min. The detector response was linear in the concentration of 120-360 mcg/ml. The respective linear regression equation being Y=166582.24x+86439.5. The limit of detection and limit of quantification was 0.06 and 0.18 mcg/ml respectively. The percentage assay of Irinotecan HCl was 99.09 %. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Irinotecan HCl in bulk drug and in its pharmaceutical dosage form.


Cite this article:
V Kiran Kumar, N Appala Raju, Namratha Rani, JVLN Seshagiri Rao, T Satyanarayana. The Estimation of Irinotecan HCl in Parenterals by RP-HPLC. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 54-56.


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