Sohan S Chitlange, Ranjana Soni, Sagar B Wankhede, Amol A Kulkarni
Sohan S Chitlange*, Ranjana Soni, Sagar B Wankhede and Amol A Kulkarni
Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research , Pimpri, Pune-411018, Maharahtra, India.
Volume - 2,
Issue - 1,
Year - 2009
Three simple spectrophotometric methods have been developed for simultaneous estimation of dexibuprofen and paracetamol from tablet dosage form. Ethanol (95%) was used as solvent. Method-I involves, formation of Q-absorbance equation at 235.5
nm (isoabsorptive point) and 249.5 nm ( max of paracetamol); Method-II simultaneous equation method involves the measurement of absorbances at two wavelengths 223 nm ( max of dexibuprofen) and 249.5 nm ( max of paracetamol) and Method-III multicomponent mode of analysis involves the measurement of absorbances at two wavelengths 223 nm ( max of dexibuprofen) and 249.5 nm ( max of paracetamol); The linearity lies between 2-7 g/ml for dexibuprofen and 4-14 g/ml for paracetamol for all the three methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 1. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of dexibuprofen and paracetamol in bulk and combined dosage form.
Cite this article:
Sohan S Chitlange, Ranjana Soni, Sagar B Wankhede, Amol A Kulkarni. Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol. Asian J. Research Chem. 2(1): Jan.-March, 2009;Page 30-33.