ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Jagjitsingh C Girase, G Venkateshwarlu, Saurabh Kumar Banerjee

Email(s): saurabhk77@gmail.com

DOI: Not Available

Address: Jagjitsingh C Girase1, G Venkateshwarlu 2 and Saurabh Kumar Banerjee1*
1School of Pharmacy Technology and Management, SVKM’s, NMIMS University, Shirpur Campus, Babulde, Near Bank of Tapi River, Shirpur, Dist: Dhule (M.S), India 425405
2Research and Development Division, Concept Pharmaceuticals Ltd, Aurangabad
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
A reverse phase high performance liquid chromatographic method was developed for simultaneous determination of Ceftriaxone Sodium and Sulbactam Sodium in bulk and Pharmaceutical Formulation. The separation was done by a Kromasil C18 column (250 mm × 4.6 mm, 5µm) using Acetonitrile: Buffer PH 7: Distilled Water (400:50:550, v/v/v) as mobile phase. The validation of the method was performed, and specificity, reproducibility, precision and accuracy were confirmed. The limit of detection was approximately 0.39 µg/ml for Ceftriaxone Sodium and 0.08 µg/ml for Sulbactam sodium. Due to simplicity and accuracy the method particularly suitable for routine pharmaceutical quality control.


Cite this article:
Jagjitsingh C Girase, G Venkateshwarlu, Saurabh Kumar Banerjee. Development and Validation of RP-HPLC Method for Simultaneous Determination of Ceftriaxone Sodium and Sulbactam Sodium in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 2(3): July-Sept., 2009, page 280-284.


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