ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M Rama kotaiah, B Ganesh, KB Chandra Sekhar, Shaik Harun Rasheed, Y Venkateswarlu, B Dhandapani

Email(s): mrk.pharma@gmail.com , dhandapanirx@gmail.com

DOI: Not Available

Address: M Rama kotaiah1*, B Ganesh1, KB Chandra Sekhar1, Shaik Harun Rasheed1, Y Venkateswarlu2 and B Dhandapani3
1Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur – 515002, Andhra Pradesh
2Dept.of Pharmaceutical Analysis, Donbosco College of Pharmacy, Pulladi Gunta, Etukuru, Guntur, (A. P.)
3Dept.of Pharmaceutical Analysis, A. M. Reddy Memorial College of Pharmacy, Narasaraopet, Guntur District – 522601, (A.P.)
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010


ABSTRACT:
A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the estimation of Trandolapril in bulk and pharmaceutical dosage forms. Quantification was carried out with percolated silica gel 60F 254 as stationary phase and mobile phase consisting of chloroform: methanol: aceticacid (8:1.5:0.5 v/v/v). The detection of spot was carried out at 212 nm using Camag TLC scanner 3 with WinCAT software. The method was validated in terms of linearity, accuracy, precision and specificity. The Rf value of trandolapril was found to be 0.54 (±0.03). The calibration curve was found to be linear between 25 to 150 ng/spot for trandolapril. The limit of detection and the limit of quantification for the trandolapril were found to be 10 ng/spot and 24 ng/spot. The proposed method can be successfully used for the estimation of drug content of different marketed formulations simultaneously on a single plate and provides a faster and cost effective quality control tool for routine analysis of Trandolapril as bulk drug and in tablet dosages forms.


Cite this article:
M Rama kotaiah, B Ganesh, KB Chandra Sekhar, Shaik Harun Rasheed, Y Venkateswarlu, B Dhandapani. HPTLC Method Development and Validation for the Estimation of Trandolapril in Bulk and Its Formulations. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 158-160.


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