Y Rajendraprasad, M Bhagavan Raju, KK Rajasekhar, S Sowjanya
Y Rajendraprasad1, M Bhagavan Raju2, KK Rajasekhar3* and S Sowjanya3
1Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam- 530003, AP, India
2CMR College of Pharmacy, Hyderabad, AP, India
3Dept. of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati -517503, AP
Volume - 3,
Issue - 2,
Year - 2010
The present work describes the insilico prodrug designing of Tanomastat, a matrix metalloproteinase inhibitor. Tanomastat was selected as a lead and a series of prodrug-like molecules derived from it were generated. The pharmacokinetic and toxicity profile of these prodrug-like molecules was obtained by using ADME and TOX boxes web version of pharma Algorithms and ACD labs Chem Sketch software version 12.0. All prodrug-like molecules were predicted to be lipophilic, less toxic with an enhaced protein binding and better therapeutic efficacy.In conclusion, ADME and Toxicity properties of these molecules suggest advantages over Tanomastat.
Cite this article:
Y Rajendraprasad, M Bhagavan Raju, KK Rajasekhar, S Sowjanya. Insilico Prodrug Designing of Some Matrix Metallo Proteinase Inhibitors Derived From Tanomastat. Asian J. Research Chem. 3(2): April- June 2010; Page 411-415.