ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): V Murugan, S Revathi, K Sumathi, Geetha KM, Kalpana Divekar

Email(s): divekarkalpana@yahoo.com

DOI: Not Available

Address: V Murugan2, S Revathi1, K Sumathi3, Geetha KM 2 and Kalpana Divekar2*
1JSS College of Pharmacy, Ooty, Tamilnadu
2Dayanandasagar College of Pharmacy, Bangalore, Karnataka
3JKKMMRS college of Pharmacy, Kumarapalayam,Tamilnadu
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
A series of 1 - [Bis - N, N- (2- Chloroethyl) aminoacetyl] -3,5 - disubstituted -1,2 pyrazolines have been synthesized by the treatment of 1 - [Bis - N, N - (2-hydroxyethyl) aminoacetyl] - 3,5 - disubstituted -1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.


Cite this article:
V Murugan, S Revathi, K Sumathi, Geetha KM, Kalpana Divekar. Synthesis of Some 1 - [Bis - N, N - (2 - Chloroethyl) Aminoacetyl] - 3, 5-Disubstituted -1, 2 - Pyrazolines as Possible Alkylating Anticancer Agents. Asian J. Research Chem. 3(2): April- June 2010; Page 496-499.


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