Prabhakar Panzade, Prashant Puranik, Vipul Mogal, Mayur Patni
Prabhakar Panzade*, Prashant Puranik, Vipul Mogal and Mayur Patni
Government College of Pharmacy, Vedant Road, Osmanpura, Aurangabad-431005
Volume - 3,
Issue - 3,
Year - 2010
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Granisetron hydrochloride in bulk and pharmaceutical dosage form. The developed UV spectrophotometric method is based on measurement of absorption at maximum wavelength 302.80 nm. The developed method was validated with respect to linearity, precision, accuracy and specificity, according to the ICH guidelines. Beer’s law was obeyed in the concentration range of 5-30 µg/ml having line equation y = 0.03315x + 0.01533 with correlation coefficient of 0.99981. The percentage recovery of Granisetron hydrochloride ranged from (101.6298±1.0547) in pharmaceutical dosage form. Results of the analysis were validated statistically and by recovery study.
Cite this article:
Prabhakar Panzade, Prashant Puranik, Vipul Mogal, Mayur Patni. Development and Validation of UV Spectrophotometric Method of Granisetron Hydrochloride in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 634-636.