ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rele R.V.., Warkar C.B.

Email(s): warkarchandan@rediffmail.com

DOI: Not Available

Address: Rele R.V.* and Warkar C.B.
D. G. Ruparel College, Matunga, Mumbai 400 016
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
A gradient reverse phase HPLC method was developed and validated for simultaneous estimation of ciprofloxacin hydrochloride and dexamethasone in pharmaceutical dosage form i.e. ophthalmic solution using Nucleosil C18 (15cm x 4.6mm, 5µm) column with a flow rate of 1.2 ml/minute and detection of 265nm. The mobile phase A consisted of 50 milli molar citric acid and potassium phosphate buffer. The mobile phase B consisted of 100 % v/v acetonitrile. The method was validated for system suitability, linearity, accuracy and precision. The system suitability parameters like resolution, theoretical plates and tailing factor were evaluated. The linear range for ciprofloxacin was 3 µg/ml – 55 µg/ml and for dexamethasone was 1 µg/ml – 16 µg/ml. The method has been successfully used to analyze pharmaceutical dosage form i.e. ophthalmic solution containing ciprofloxacin hydrochloride and dexamethasone with good recoveries.


Cite this article:
Rele R.V.., Warkar C.B.. Simultaneous Determination of Ciprofloxacin Hydrochloride and Dexamethasone in Ophthalmic Solution by Reversed Phase High Performance Liquid Chromatography. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 673-677

Cite(Electronic):
Rele R.V.., Warkar C.B.. Simultaneous Determination of Ciprofloxacin Hydrochloride and Dexamethasone in Ophthalmic Solution by Reversed Phase High Performance Liquid Chromatography. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 673-677   Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-3-41


Recomonded Articles:

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Chavan Pooja Ajit, Avinash Mahadeo Bhagwat, Atul Prabhakar Chaudhari

DOI: 10.52711/0974-4150.2021.00061         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Nachiket S. Dighe, Priyanka R. Varade, Ganesh S. Shinde, Priya S. Rao

DOI: 10.5958/0974-4150.2019.00028.2         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): Nikita N. Patel, Charmy S. Kothari

DOI:         Access: Open Access Read More

Author(s): RB Kakde, VH Kotak, DL Kale

DOI:         Access: Open Access Read More

Author(s): Shashi Ravi Suman Rudrangi, Vijaya Kumar Bontha, Venkata Reddy Manda, Srinivas Bethi

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags