ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): V. Murugan, Brijesh Joshi, Geetha K.M.

Email(s): brijesh.joshi24@gmail.com

DOI: Not Available

Address: V. Murugan, Brijesh Joshi* and Geetha K.M.
Department of Pharmaceutical Chemistry and Pharmacology, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangaluru – 5600078, Karnataka state
*Corresponding Author

Published In:   Volume - 3,      Issue - 3,     Year - 2010


ABSTRACT:
2-Imino-3-(5-aryl-1, 3, 4-thiadiazolyl)-1,3-thiazol-4-one (E) have been synthesized from Arylaldehyde and Thiosemicarbazide. Condensation of the Iminothiazol-4-one with different substituted aromatic aldehyde and fused sodium acetate in glacial acetic acid to get 2-Imino-5-(4-substituted arylidene)-3-(5-aryl-1, 3, 4-thiadiazol-2-yl) -1,3-thiazol-4-one (F1-7). The structures of the synthesized compounds were conformed on the basis of spectral data. The compounds have been screened for their possible CNS depressant and anti microbial activities. Among the synthesized compounds F1, F2, F4 and F7 showed significant CNS depressant activity and compounds F1, F2, F4 and F6 showed moderate antimicrobial activity.


Cite this article:
V. Murugan, Brijesh Joshi, Geetha K.M.. Synthesis of 2-Imino-3-(5-Aryl-1, 3, 4-Thiadiazol-2-Yl)-5-Arylidene-1, 3-Thiazol-4-One as Potent CNS Depressant and Antimicrobial Agents. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 698-702.


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DOI: 10.5958/0974-4150 

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