ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): R.K. Nanda, V.V. Bhagwat, S.E. Potawale, S.C. Hamane

Email(s): rabindrananda@rediffmail.com

DOI: Not Available

Address: R.K. Nanda*, V.V. Bhagwat, S.E. Potawale and S.C. Hamane
D.Y. Patil Pratishthan’s Padmashree Dr. D.Y.Patil Institute of Pharmaceutical, Sciences and Research, Pimpri, Pune-411018, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
A new simple high performance thin layer chromatographic (HPTLC) method for simultaneous determination of Cefixime and Potassium Clavulanate combined tablet dosage form has been developed and validated. The separation was carried out on Merck aluminum plates precoated with silica gel 60 F254, using Acetone: Water: Acetic acid 8: 0.8: 1.2 (v/v/v) as mobile phase. The separated spots were stained with Iodine vapors and scanned at 410 nm. The retention factor for Cefixime and Potassium Clavulanate were found to be 0.23 ± 0.01 and 0.68 ± 0.01. The method was validated with respect to linearity, accuracy, precision, robustness, in accordance with ICH guidelines. The calibration curve was found to be linear over a range of 0.5–3.0 µg per spot for Cefixime and 0.310-1.870 µg per spot for Potassium Clavulanate. The method has been successfully applied for the analysis of drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 100.29± 0.9933 for Cefixime and 100.95± 1.005 for Potassium Clavulanate.


Cite this article:
R.K. Nanda, V.V. Bhagwat, S.E. Potawale, S.C. Hamane. Development and Validation of A HPTLC Method for Simultaneous Densitometric Analysis of Cefixime and Potassium Clavulanate as the Bulk Drugs and in the Tablet Dosage Form. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 998-1001.


Recomonded Articles:

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): R.K. Nanda, S.E. Potawale, V.V. Bhagwat, S.C.Hamane, R. S. Deshmukh

DOI:         Access: Open Access Read More

Author(s): VB Kshirsagar, UA Deokate, VB Bharkad, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): Sachin R Shinde , Suvarna I Bhoir, Namdev S Pawar, Suman B Yadav, Ajay S Ghumatkar, Ashok M Bhagwat

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags