An improved synthesis of 3-oxo-4-aza-5a-androst-1-ene-17ß-(N-tert-butylcarboxamide), commonly known as finasteride (1), a drug widely used for the treatment of benign prostatic hyperplasia (BPH), has been implemented via seven steps in an overall yield of 20.01% starting from 4-androsten-3,17-dione (AD). Conditions of several steps have been improved to be less expensive and more commercially viable compared to reported synthesis in literature.
Cite this article:
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.