Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

An improved synthesis of finasteride from 4-androsten-3,17-dione

Author(s): Nguyen Hai Nam, Ngo Anh Ngoc

Email(s): nhnam@hotmail.com

DOI: Not Available

Address: Nguyen Hai Nam* and Ngo Anh Ngoc
Department of Pharmaceutical Chemistry and Center for New Drugs Discovery and Development (C3D), Hanoi University of Pharmacy 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi, Vietnam
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

 View HTML        View PDF

ABSTRACT:
An improved synthesis of 3-oxo-4-aza-5a-androst-1-ene-17ß-(N-tert-butylcarboxamide), commonly known as finasteride (1), a drug widely used for the treatment of benign prostatic hyperplasia (BPH), has been implemented via seven steps in an overall yield of 20.01% starting from 4-androsten-3,17-dione (AD). Conditions of several steps have been improved to be less expensive and more commercially viable compared to reported synthesis in literature.


Keywords:

Cite this article:
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.

Cite(Electronic):
Nguyen Hai Nam, Ngo Anh Ngoc. An improved synthesis of finasteride from 4-androsten-3,17-dione. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1099-1102.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-4-69


Recomonded Articles:

Pyridine and Its Biological Activity: A Review

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Microwave Assisted Synthesis and Characterization of Phenytoin

Author(s): Mukesh K. Nagar, Karishma R. Waghmare, P.N. Dhabale, Pradeep D. Chanekar, Suresh Bhatia

DOI:         Access: Open Access Read More

Synthesis and Characterization Co and Mg Co-doped TiO2 Nanoparticles

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde

Author(s): Suha K. Al-Mosawi, Hanan A. Al-Hazam, Abbas F. Abbas

DOI: 10.5958/0974-4150.2019.00031.2         Access: Open Access Read More

Identification synthesis of process-related impurities (substances) ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate [key intermediate of Olmesartan medoxomil (Anti hypertensive drug)]

Author(s): G. Venkannaa, G. Madhusudhan, K. Mukkanti, Y. Sampath Kumar

DOI: 10.5958/0974-4150.2015.00051.6         Access: Open Access Read More

Synthesis, Characterisation, DNA binding/cleavage, anticancer and antimicrobial activity of Ternary Copper(II) Complexes

Author(s): S. Dhakshanamoorthy, M. Murali Krishnan, M.N. Arumugham

DOI: 10.5958/0974-4150.2017.00052.9         Access: Open Access Read More

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2017.00002.5         Access: Open Access Read More

Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Synthesis and Biological Screening of Novel Aminoalkyl Substituted Azaphenothiazine

Author(s): P. Valentina, K. Ilango, Deepak Jain, Prerna Shukla

DOI:         Access: Open Access Read More

Synthon Approach in Designing Organic Synthesis

Author(s): A. A. Kulkarni, S. R. Doshi, R. K. Nanda, N. R. Chatterjee

DOI:         Access: Open Access Read More

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Synthesis and antimicrobial evaluation of Azetidinone derivatives of pyridine containing hydrazides

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Schiff base metal complexes: Synthesis, Characterization, Thermal Analysis and Antibacterial Activity

Author(s): Tuly Paul, Faruk Hossen, Kudrat-E-Zahan, Masuqul Haque, Saddam Hossain, Rausan Zamir, Ali Asraf

DOI: 10.5958/0974-4150.2020.00052.8         Access: Open Access Read More

A Short Review on Structures and Synthesis of some Heterocyclic Compounds

Author(s): Azam Z. Shaikh, Harsha Jadhav, Darshana M. Borse, Ritik. S. Jain

DOI: 10.5958/0974-4150.2021.00028.6         Access: Open Access Read More

Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

A Review on Recent Trends in the Bioactive Studies of Pyrazole Derivatives

Author(s): Maddineni Aruna Kumari, Chunduri Venkatarao

DOI: 10.5958/0974-4150.2020.00072.3         Access: Open Access Read More

Synthesis, characterization and anti-inflammatory activity some 1-(4-substituted)-2-(-4-(piperazine-1-yl) bis-thiazole-5-yl) 2-methyl-4-nitro-1h-imidazole-1-yl) ethanone

Author(s): Aejaz Ahmed, Khurshid I. Molvi, Gulam Javed Khan

DOI: 10.5958/0974-4150.2017.00027.X         Access: Open Access Read More

Reduction of Schiff Bases with Sodium Borohydride Possessing Antibacterial Activity

Author(s): S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute

DOI:         Access: Open Access Read More

Synthesis and Biological Activities of Some Benzothiazole Derivatives

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Synthesis and Biological Evaluation of Some Substituted Amino Thiazole Derivatives

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



A New Isocratic RP-HPLC Assay Method Development and Validation of Febuxostat in Tablet Dosage Form
1,3,4- Oxadiazole, A Complete Review on Biological Activities of Newly Synthesized Derivatives
A Review on Analytical Method Development and Validation of Flecainide using HPLC
Tridhatugarbha Pottali – An Overview
A Non-aqueous Potentiometric Titration Method for Validation of Emtricitabine from Pharmaceutical Dosages
In Silico Study of CNS Depressant Drug
Fabrication and Characterisation of Cross-linked Cellulose hydrogel from Residual papers
Novel Separation Processes in Chemical Process Engineering and Desalination Science - A Vast Vision for the Future
Anti-urolithiatic effect of Ethanolic extract of Bryophyllum pinnatum (Lam) against Chemicals Induced Renal Calculi in rats
Protective effect of Thiocolchicoside against Haloperidol Induced Orofacial Dyskinesia and Catalepsy in Rats
Review of Drug Repositioning in Cancer Therapeutics
Activated carbon from macadamia nutshells for removal of p-Nitrophenol from real wastewater: Thermodynamic evaluation
Review on Colon Targeted Drug Delivery System
Exploring the Effects of Polyacrylic Acid on Triton-X-100 Aqueous Solutions: Density, Viscosity and Ultrasonic Velocity Analysis
Formulation and Evaluation of Amaranthus dubius herbal gel
Estimation of Imatinib Mesylate by Extractive Colorimetric Methods in Bulk and Pharmaceutical Dosage Form
Qualitative and Quantitative Analysis of the Phytochemicals in Aerva lanata
Co-Solvent effect and Kinetics of Alkaline Hydrolysis of Butyle Salicylate
A Systematic Review on Ethnobotanical and Pharmacological Aspects of Croton plant Codiaeum variegatum (L.)
Review on Thiazolo-Triazole as a Promising Anticancer agent

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 409
Yesterday: 1156
Total: 1677444