Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography

Author(s): Ravindra J. Jarag, A.R. Paradkar

Email(s): ravindrajarag@gmail.com

DOI: Not Available

Address: Ravindra J. Jarag1* and A.R. Paradkar2
1Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra India-416013
2Bharati Vidyapeeth Poona College of Pharmacy, Pune, Maharashtra India -411038
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011

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ABSTRACT:
In present study, RP-HPLC method was developed for the quantitative estimation of Felodipine (calcium channel blocker used in the treatment of hypertension and angina pectoris) in agglomerates prepared by Crystallo-co-agglomeration technique. In RP-HPLC (binary gradient system consists of Jasco 2000 plus) method, felodipine was determined by isocratic system using methanol 0.055M phosphate buffer (83:17 v/v pH=3 ± 0.1) as mobile phase. Hydrochlorthaizide was adopted as an internal standard. Detection was carried out with UV detection at 232 nm. The proposed developed method is simple, sensitive, accurate, precise and rapid. The method is valid as per ICH guidelines.


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Cite this article:
Ravindra J. Jarag, A.R. Paradkar. Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography. Asian J. Research Chem. 4(1): January 2011; Page 88-90.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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DOI: 10.5958/0974-4150 

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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