ABSTRACT:
In present study, RP-HPLC method was developed for the quantitative estimation of Felodipine (calcium channel blocker used in the treatment of hypertension and angina pectoris) in agglomerates prepared by Crystallo-co-agglomeration technique. In RP-HPLC (binary gradient system consists of Jasco 2000 plus) method, felodipine was determined by isocratic system using methanol 0.055M phosphate buffer (83:17 v/v pH=3 ± 0.1) as mobile phase. Hydrochlorthaizide was adopted as an internal standard. Detection was carried out with UV detection at 232 nm. The proposed developed method is simple, sensitive, accurate, precise and rapid. The method is valid as per ICH guidelines.
Cite this article:
Ravindra J. Jarag, A.R. Paradkar. Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography. Asian J. Research Chem. 4(1): January 2011; Page 88-90.
Cite(Electronic):
Ravindra J. Jarag, A.R. Paradkar. Development and Validation of Method for Quantitative Estimation of Felodipine Agglomerates by High Pressure Liquid Chromatography. Asian J. Research Chem. 4(1): January 2011; Page 88-90. Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-1-18