ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Shubhangi S. Soman, Tirth H. Thaker, Radhika D. Baloni

Email(s): shubhangiss@rediffmail.com

DOI: Not Available

Address: Shubhangi S. Soman*, Tirth H. Thaker and Radhika D. Baloni
Department of Chemistry, Faculty of Science, The M.S. University of Baroda, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011


ABSTRACT:
Knoevenagel condensation of 2-hydroxy-1-naphthaldehyde with ethylacetoacetate gave 2-acetyl-benzo[f]chromen-3-one (1). Bromination of (1) with bromine in chloroform gave 2-(2-bromoacetyl)-benzo[f]chromen-3-one (2), which on condensation with different primary aromatic amines gave corresponding amino acetyl derivatives (3a-c). Similar series of reactions were carried out on salicylaldehyde and resorcaldehyde, which gave corresponding 3-aminoacetyl coumarin and 7-hydroxy-3-aminoacetyl coumarin derivatives. Screening of these compounds for antibacterial activity against Staphylococus aureus (Gram +ve), Micrococus leuteus (Gram +ve) and DH5a-Escherichia coli (Gram -ve) show good antibacterial activity.


Cite this article:
Shubhangi S. Soman, Tirth H. Thaker, Radhika D. Baloni. Synthesis of Aminoacetylcoumarins and Aminoacetylnaphthocoumarins and their Antibacterial activity study. Asian J. Research Chem. 4(1): January 2011; Page 132-136.


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