Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis of Aminoacetylcoumarins and Aminoacetylnaphthocoumarins and their Antibacterial activity study

Author(s): Shubhangi S. Soman, Tirth H. Thaker, Radhika D. Baloni

Email(s): shubhangiss@rediffmail.com

DOI: Not Available

Address: Shubhangi S. Soman*, Tirth H. Thaker and Radhika D. Baloni
Department of Chemistry, Faculty of Science, The M.S. University of Baroda, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011

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ABSTRACT:
Knoevenagel condensation of 2-hydroxy-1-naphthaldehyde with ethylacetoacetate gave 2-acetyl-benzo[f]chromen-3-one (1). Bromination of (1) with bromine in chloroform gave 2-(2-bromoacetyl)-benzo[f]chromen-3-one (2), which on condensation with different primary aromatic amines gave corresponding amino acetyl derivatives (3a-c). Similar series of reactions were carried out on salicylaldehyde and resorcaldehyde, which gave corresponding 3-aminoacetyl coumarin and 7-hydroxy-3-aminoacetyl coumarin derivatives. Screening of these compounds for antibacterial activity against Staphylococus aureus (Gram +ve), Micrococus leuteus (Gram +ve) and DH5a-Escherichia coli (Gram -ve) show good antibacterial activity.


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Cite this article:
Shubhangi S. Soman, Tirth H. Thaker, Radhika D. Baloni. Synthesis of Aminoacetylcoumarins and Aminoacetylnaphthocoumarins and their Antibacterial activity study. Asian J. Research Chem. 4(1): January 2011; Page 132-136.

Cite(Electronic):
Shubhangi S. Soman, Tirth H. Thaker, Radhika D. Baloni. Synthesis of Aminoacetylcoumarins and Aminoacetylnaphthocoumarins and their Antibacterial activity study. Asian J. Research Chem. 4(1): January 2011; Page 132-136.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-1-29


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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