ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Snehal S. Ingale, Dipali M. Mehetre, Dhanshri J. Desai, Madhusmita Sahoo, Vishnu P. Choudhari, Bhanudas S. Kuchekar

Email(s): viraj1404@rediffmail.com

DOI: Not Available

Address: Snehal S. Ingale, Dipali M. Mehetre, Dhanshri J. Desai, Madhusmita Sahoo, Vishnu P. Choudhari* and Bhanudas S. Kuchekar
MAEER’S Maharashtra Institute of Pharmacy, S.No. 124, MIT Campus, Paud Road, Kothrud, Pune-411038, (MS) India
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2011


ABSTRACT:
Two simple, economical, precise and accurate methods for simultaneous determination of Drotaverine Hydrochloride (DRO) and Diclofenac Potassium (DIC) in combined tablet dosage form has been developed. The first method is based on Ratio Spectra Derivative and second method is Area Under Curve (AUC) Spectrophotometry. The amplitudes at 251.96 nm and 258.46 nm in the first derivative ratio spectra were selected to determine DRO and DIC, respectively and wavelength ranges of 237.4-247.2 nm and 271.1-282.8 nm were selected to determine DRO and DIC by AUC method, respectively in combined formulation. Beer’s law is obeyed in the concentration range of 8-40 µg mL-1 for DRO and 5-25 µg mL-1 for DIC for both the methods. The % assay for commercial formulation was found to be in the range 99.01 – 100.89% for DRO and 98.91 – 101.72% for DIC by the proposed methods. ICH guidelines were followed and methods were validated with respect to linearity, precision and accuracy. Recovery by both the methods was found in the range of 99.72 - 101.34% for DRO and 99.06 - 100.45% for DIC.


Cite this article:
Snehal S. Ingale, Dipali M. Mehetre, Dhanshri J. Desai, Madhusmita Sahoo, Vishnu P. Choudhari, Bhanudas S. Kuchekar. Spectrophotometric Simultaneous Determination of Drotaverine Hydrochloride and Diclofenac Potassium in Combined Tablet Dosage Form by Ratio Derivative and Area Under Curve method. Asian J. Research Chem. 4(1): January 2011; Page 35-39.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

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