ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): B. Anupama, M. Sunitha, C. Gyana Kumari

Email(s): prof_c_gyana@yahoo.co.in

DOI: Not Available

Address: B. Anupama, M. Sunitha and C. Gyana Kumari*
Department of Chemistry, Osmania University, Hyderabad -500007, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
The Schiff bases namely 5-Me SALAAP, 3-OMe SALAAP, 3-Br, 5-Cl SALAAP have been prepared by reacting 4-amino antipyrine with 5-methyl salicylaldehyde/3-methoxy salicylaldeyde /3-Br, 5-Cl salicylaldehyde. The Cu(II) complexes have been prepared by reacting copper(II) chloride with those of Schiff bases in alcoholic medium .The complexes are non electrolytes in DMSO. These have been characterized by using elemental analysis, IR, UV-VIs, 1H, 13C NMR, Mass spectra, ESR spectra, Magnetic susceptibility, conductance measurements and thermal (TGA and DTA) anaylsis. The complexes were found to have composition ML2.On basis of elemental and spectral studies, six coordinated geometry is assigned for these complexes. The Schiff bases act as tridentate and coordinate through the azomethine nitrogen, carbonyl oxygen and phenolic oxygen respectively. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods. The synthesized ligands and their metal complexes were screened against bacteria. (E.coli and Staphylococcus aureus). The activity data show that the metal complexes are more potent than Schiff bases.


Cite this article:
B. Anupama, M. Sunitha, C. Gyana Kumari. Synthesis, Characterization, DNA Binding and Antimicrobial Activity of Copper (II) Complexes with 4-Aminoantipyrine Schiff Bases. Asian J. Research Chem. 4(10): Oct., 2011; Page 1529-1535.


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