ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole

Email(s): nikhilamnerkar@gmail.com

DOI: Not Available

Address: KP Bhusari1, ND Amnerkar2*, PB Khedekar1, MK Kale2 and RP Bhole1
1Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441 110, M.S. India
2Kamla Nehru College of Pharmacy, Butibori-441 108, M.S., India
*Corresponding Author

Published In:   Volume - 1,      Issue - 2,     Year - 2008


ABSTRACT:
A series of sulphonamide derivatives having benzothiazole nucleus have been synthesized by condensation of 2- aminobenzothiazole with 4-acetamidobenzenesulphonyl chloride derivatives in pyridine-acetic anhydride mixture. The identity of the compounds 4-acetamido-N-(1, 3-benzothiazol-2-yl) benzene sulphonamide and 4-amino-N-(1,3- benzothiazol-2-yl)benzene-sulphonamide has been characterized by elemental analysis and spectral data. All the test compounds have been assayed in vitro for antibacterial activity against B. subtilis and E. coli, antifungal activity against C. albicans and the antimycobacterial activity against H37Rv strain of mycobacterium tuberculosis. The test compounds showed significant antibacterial, antifungal and antimycobacterial activity against the microbial strains used.


Cite this article:
KP Bhusari, ND Amnerkar, PB Khedekar, MK Kale, RP Bhole. Synthesis and In Vitro Antimicrobial Activity of Some New 4-Amino-N-(1,3- Benzothiazol-2-yl) benzenesulphonamide Derivatives. Asian J. Research Chem. 1(2): Oct.-Dec. 2008; Page 53-58.


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