H.V. Shahare, G.R. Pawar, S.S. Patil, P.D. Patil
H.V. Shahare*, G.R. Pawar, S.S. Patil and P.D. Patil
Department of Pharmaceutical Chemistry, SNJB’S Shriman Sureshdada Jain College of Pharmacy, Chandwad, Nashik, MS, India-423101
Volume - 4,
Issue - 2,
Year - 2011
The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic-resistant pathogens, fueling an ever-increasing need for new drugs. In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of bromo and chloro acetophenone with appropriate aromatic aldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by their physical constants, TLC, IR and NMR spectroscopy. Further all the synthesized compounds were successfully evaluated for their antibacterial and antifungal activities by cup-plate method.
Cite this article:
H.V. Shahare, G.R. Pawar, S.S. Patil, P.D. Patil. Synthesis and Biological Evaluation of New Chalcone Analogs. Asian J. Research Chem. 4(2): February 2011; Page 237-240.