ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

Email(s): viruchem765@gmail.com

DOI: 10.5958/0974-4150.2017.00012.8   

Address: Virupakshi Prabhakar1*, Kondra Sudhakar Babu2, L.K. Ravindranath2, M. Sahanoor Basha3, J. Latha4
1Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University- Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., INDIA.
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), INDIA.
3Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University- Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., INDIA.
4Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S.K. University, Ananthapuramu – 515003 (A.P), India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 2,     Year - 2017


ABSTRACT:
Di azepines, which were synthesized by different methods shown in literature and also Di azepines are great importance in heterocyclic chemistry and more importance in biology and pharmacology. Di azepines are very biological active molecules. In this work A new series of 1, 5-Benzodizepine derivatives were synthesized from chalcones and evaluated for their Antimicrobial activities. First Chalcones were prepared by treatment of Thieno [2, 3-d] pyrimidine-6-carbaldehyde with different acetophenones by Claisen-Schimidt Condensation. Various Benzodiazepines derivatives were prepared by reaction of Chalcone in DMF with o-phenylene di amine in presence of piperidine. The structures of the newly synthesized Benzodiazepine derivatives have been established on the basis of their spectral data. The synthesized selected compounds were evaluated for their antimicrobial activities.


Cite this article:
Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha. Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening. Asian J. Research Chem. 2017; 10(2):71-84. doi: 10.5958/0974-4150.2017.00012.8


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