Three simple, sensitive and cost effective Spectrophotometric methods are developed for the determination of Racecadotril in bulk drug and pharmaceutical dosage forms. These methods are based on the oxidation of Racecadotril by ferric chloride in presence of 1, 10-phenanthroline (Method A) or 2, 2'bipyridyl (Method B) or potassium ferricyanide (Method C). The colored complex formed was measured at 510, 520 and 720 nm for methods A, B and C respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer’s law is valid within a concentration range of 25-100 µg/ml, 20-120µg/ml and 200-1200 µg/ml for method A, B and C respectively. The mean percentage recoveries are 99.82, 100.1, 99.86 for method A, B and C respectively. The developed methods are applied for the determination of Racecadotril in bulk and its pharmaceutical formulations without any interference from excipients.
Cite this article:
Ch. Narasimha Raju B.H., N. Delhiraj, G. Devala Rao. Spectrophotometric Methods for the Determination of Racecadotril in Bulk and Pharmaceutical Dosage Forms. Asian J. Research Chem. 4(4): April 2011; Page 548-550.