ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sunil Kumar, Surrinder Koul, Ajay Kumar Meena, A.K. Saxena, O.P. Suri, K.L. Dhar

Email(s): dharkl@yahoo.com

DOI: Not Available

Address: Sunil Kumar1, Surrinder Koul2, Ajay Kumar Meena4, A.K. Saxena3, O.P. Suri1 and K.L. Dhar1*
1Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001, India
2Department of Bio-organic Chemistry, IIIM Jammu Tawi 180001, India
3Division of Pharmacology, IIIM Jammu Tawi, 180001 India
4National Institute of Ayurvedic Pharmaceutical Research, Moti Bagh Road, Patiala, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2011


ABSTRACT:
Plants, source of various bioactive compounds have played crucial role in development of several clinically useful anticancer agents’ viz., vincristin, vinblastin, camptothecin derivatives and taxol. Combretastatin, a potent anticancer molecule was first isolated from plant. In this continuation a series of combretastatin analogues has been synthesized on the basis of our butterfly model with two wings as aryl groups and connecting carbon chain as the body. In present study we have synthesized combretastatin analogues of different substitutions, showed potent anticancer activity against different cell lines in different fashion according to substitution. Compound 6 showed marked anticancer activity against colo-205 cell lines (colon cancer).


Cite this article:
Sunil Kumar, Surrinder Koul, Ajay Kumar Meena, A.K. Saxena, O.P. Suri, K.L. Dhar. Synthesis and Antitumor Activity of Combretastatin Analogues. Asian J. Research Chem. 4(6): June, 2011; Page 902-904.


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DOI: 10.5958/0974-4150 

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