ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Maste Meenaxi M., Ainapure R., Patil P. B., Bhat A. R.

Email(s): menai_us@yahoo.com

DOI: Not Available

Address: Maste Meenaxi M.1*, Ainapure R.2, Patil P. B.2, Bhat A. R.2
KLE University’s College of Pharmacy, JNMC Campus, Belgaum-590 010, Karnataka
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
The Nitro containing 5-oxo-[1,2,4,]triazole ring were synthesized by the nitration of compound (I) with nitric acid. Then acetic acid ethyl esters containing 5-oxo-[1,2,4,]triazole ring (II) were synthesized by the condensation of compound (I) with ethyl chloroacetate in basic media. The reaction of compound (II) with hydrazine hydrate led to formation of acid hydrazide (III). The treatment of compound(III) with different aromatic aldhydes resulted in the formation of arylidene hydrazide’s as target compounds. The structure of the synthesized Compounds were evaluated by IR, 1H NMR spectra and elemental method of analysis. All the synthesized compounds were screened for their anti-tubercular activity. Anti-tubercular activity was carried out by using middle brook 7H9 broth base (M198) medium against Mycobacterium tuberculosis of H37Rv Strain. Streptomycin was used as standard drug for comparison.


Cite this article:
Maste Meenaxi M., Ainapure R., Patil P. B., Bhat A. R.. Triazolone and their Derivatives for Anti -Tubercular Activities. Asian J. Research Chem. 4(7): July, 2011; Page 1050-1054.


Recomonded Articles:

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, J. Latha, B.Venkateswarlu

DOI: 10.5958/0974-4150.2017.00011.6         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags