ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Maste M. M., Jeyarani P., Kalekar M. C., Bhat A. R.

Email(s): menai_us@yahoo.com

DOI: Not Available

Address: Maste M. M.*, Jeyarani P., Kalekar M. C. and Bhat A. R.
Department of Pharmaceutical Chemistry, K. L.E.U’s College of Pharmacy, Belgaum
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
The present research work was aimed to synthesize some benzimidazole acetic acid derivatives and also the derivatives associated with 1,2,4 triazolone and was investigated for their biological activities. A two different series of compounds were synthesized, 4-[(2-aryl methyl- 1H-benzimidazol-1-yl) acetyl] 5 nitro-2,4 –dihydro-3H-1,2,4 triazol-3-one and 4-[(2-aryl methyl-1H-benzimidazol-1-yl)methyl] 5 nitro-2,4- dihydro-3H-1,2,4 triazol-3-one. The newly synthesized compounds have been characterized by their analytical and spectral (IR and 1H NMR, C13 NMR, mass spectra) properties. All the compounds have been screened for their anti tubercular and antimicrobial activities by standard methods. Results of activities reveal that compound shown promising anti tubercular activity at both the concentration compared to standard drug streptomycin, and shown good antimicrobial activities.


Cite this article:
Maste M. M., Jeyarani P., Kalekar M. C., Bhat A. R.. Synthesis and Evaluation of Benzimidazole Derivatives for Anti-tubercular and Antimicrobial Activities. Asian J. Research Chem. 4(7): July, 2011; Page 1055-1058.


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