Monica Arora, J. Saravanan, S. Mohan, Shivaji Bhattacharjee
Monica Arora*, J. Saravanan, S. Mohan, Shivaji Bhattacharjee
Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-50, Karnataka, India.
Volume - 5,
Issue - 11,
Year - 2012
2-Amino-4-(4-acetamido phenyl) Thiophene-3carboxamide was synthesized using versatile Gewald reaction .First step is preparation of cyanoacetamide which was carried out by condensation of ammonia (25%) and ethyl cyano acetate which was then reacted with p-acetanilido acetophenone, sulphur, diethyl amine to give 2-Amino-4-(4-acetamido phenyl) thiophene-3carboxamide.Later the compound was treated with twelve different substituted aryl aldehydes to yield twelve new Schiff bases(SM 1a-1l). The compounds were characterized IR, 1H NMR and mass spectral data and screened for antimicrobial activity.
Cite this article:
Monica Arora, J. Saravanan, S. Mohan, Shivaji Bhattacharjee. Synthesis, Characterization and Antimicrobial activity of Some Schiff Bases of 2-Amino-4-(4-Acetamido Phenyl)thiophene-3-carboxamide. Asian J. Research Chem. 5(11): Nov., 2012; Page 1360-1364.