Rajesh K. Patel, Ravi N. Patel, Dr. Ashok L. Ganure, Dr. Laxmanbhai J. Patel
Rajesh K. Patel1*, Ravi N. Patel1, Dr. Ashok L. Ganure1, Dr. Laxmanbhai J. Patel2
1Department of Pharma. Analysis, K.J. College of Pharmacy, Vadasma-382708,
2Department of Pharma. Analysis, Shree S.K. Patel College of Pharmaceutical Education and Research, Mehsana, Gujarat
Volume - 5,
Issue - 2,
Year - 2012
A Derivative Spectrophotometric method has been developed for simultaneous estimation of Ranitidine and Drotaverine in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 322 nm (?max for Ranitidine) and 306.5 nm (?max for Drotaverine). The linearity lies between 5-60µg/ml for Ranitidine and 4-20µg/ml for Drotaverine. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Ranitidine and Drotaverine in combined pharmaceutical dosage form.
Cite this article:
Rajesh K. Patel, Ravi N. Patel, Dr. Ashok L. Ganure, Dr. Laxmanbhai J. Patel. Simultaneous Estimation of Ranitidine and Drotaverine in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method. Asian J. Research Chem. 5(2): February 2012; Page 215-217.