0974-4150 (Online)
0974-4169 (Print)

Author(s): A. S. Grewal, S. K. Patro, S. K. Kanungo


DOI: Not Available

Address: A. S. Grewal1*, S. K. Patro2, S. K. Kanungo2
1Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa 125055, Haryana, India
2Institute of Pharmacy and Technology, Salipur, Cuttack 754202, Orissa, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012

The main objective was to develop and validate asimple, accurate, precise and sensitive ion-pair spectrophotometric extraction method for the assay of Ciprofloxacin (CFX) in pure drug and tablets. The method is based upon the reaction of Ciprofloxacin with methyl orange, forming a yellow colour complex in acidic medium, which is extracted in chloroform and analyzed. The extracted complexes showed absorbance maxima (?max) found to be at 429 nm. Beer's law was obeyed for a wide concentration range i.e.100-700 µg/mLas the extracted species seemed well defined and stable.Surface or an interphase adsorption phenomenon was not a problem. Optimization of the reaction was carried out with factors such as buffer strength, stability of complex, molar ratio of drug: dye and extraction time.The proposed method was validated as per ICH guidelines Q 2. The recovery studies confirmed the accuracy and precision of the method. The above method was a rapid tool for routine analysis of Ciprofloxacin in the bulk and pharmaceutical dosage forms.

Cite this article:
A. S. Grewal, S. K. Patro, S. K. Kanungo. Ion-Pair Spectrophotometric Estimation of Ciprofloxacin in bulk and pharmaceutical formulations. Asian J. Research Chem. 5(4): April 2012; Page 537-540.

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DOI: 10.5958/0974-4150 

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