Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique

Author(s): Ahmed Samir, Nagia El-Megrab, Hanaa A. Fattah, Waleed Barakat

Email(s): dr_scheva99@yahoo.com

DOI: Not Available

Address: Ahmed Samir1, Nagia El-Megrab1, Hanaa A. Fattah1, Waleed Barakat2
Departments of 1Pharmaceutics, 2Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt.
*Corresponding Author

Published In:   Volume - 5,      Issue - 4,     Year - 2012

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ABSTRACT:
The objective of present was to improve the solubility of Clonazepam (CZP), poorly water soluble drug, by solid dispersion technique using Polyethylene glycol 6000 (PEG 6000) and Urea (UR) as carriers. The Solid dispersion was prepared by physical mixing and solvent evaporation method. The interaction of the Clonazepam with PEG 6000 and UR was evaluated by the Fourier transform infrared (FTIR) spectroscopy; Differential scanning Calorimetry (DSC) and X-ray diffraction patterns (XRD). The results from the FTIR and XRD analyses showed that Solid dispersion might exist in the amorphous form. A DSC result showed that the sharp melting point was completely disappeared suggesting that the CZP molecularly dispersed in an amorphous form. Dissolution studies indicate that dissolution rate was remarkably increased in Solid dispersion as compared to the physical mixture and drug alone. Also the pharmacological studies of the selected formulations [(1:3 CZP : PEG 6000) and (1:2 CZP : Urea)] were performed. In conclusion PEG 6000 and UR can be a well utilized to increase the solubility of poorly water soluble drugs.


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Cite this article:
Ahmed Samir, Nagia El-Megrab, Hanaa A. Fattah, Waleed Barakat. Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique. Asian J. Research Chem. 5(4): April 2012; Page 483-491.

Cite(Electronic):
Ahmed Samir, Nagia El-Megrab, Hanaa A. Fattah, Waleed Barakat. Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique. Asian J. Research Chem. 5(4): April 2012; Page 483-491.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2012-5-4-8


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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DOI: 10.5958/0974-4150 

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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